Surgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules.
Surgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules.
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DOI：
10.1016/j.amjsurg.2009.08.029
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发表时间：
2010-07
影响因子：
3
通讯作者：
Parangi, Sareh
中科院分区：
文献类型：
--
作者：
Mekel, Michal;Nucera, Carmelo;Hodin, Richard A.;Parangi, Sareh
甲状腺结节患者的管理是基于建立一个准确的诊断;然而，术前区分良性和恶性病变并不总是可能使用当前的细胞学技术。对细胞学材料进行新的分子检测可能会导致更清晰的治疗算法。B-RafV 600 E突变是甲状腺癌中最常见的遗传改变，特别是在乳头状甲状腺癌（PTC）中发现，并且通常被报道与侵袭性疾病相关。使用PubMed进行的文献检索确定了所有关于甲状腺癌中B-RafV 600 E突变的识别和利用的相关文献。使用B-Raf突变检测不确定细胞学的结节的效用是有限的，因为许多这些结节（良性和恶性）不窝藏B-Raf突变。然而，当病理学家发现PTC的细胞学特征可疑时，B-RafV 600 E突变分析可以增强PTC术前风险的评估，在适当时指导更积极的初始手术管理。
Management of patients with thyroid nodules is based on establishing an accurate diagnosis; however, differentiating benign from malignant lesions preoperatively is not always possible using current cytological techniques. Novel molecular testing on cytological material could lead to clearer treatment algorithms. B-RafV600E mutation is the most common genetic alteration in thyroid cancer, specifically found in papillary thyroid cancer (PTC), and usually reported to be associated with aggressive disease. A literature search using PubMed identified all the pertinent literature on the identification and utilization of the B-RafV600E mutation in thyroid cancer. The utility of using B-Raf mutation testing for nodules with indeterminate cytology is limited since many of those nodules (benign and malignant) do not harbor B-Raf mutations. However, when the pathologist sees cytological features suspicious for PTC, B-RafV600E mutation analysis may enhance the assessment of preoperative risks for PTC, directing a more aggressive initial surgical management when appropriate.
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