Bayesian Coherence Analysis for Microcircuit Structure Learning.

Bayesian Coherence Analysis for Microcircuit Structure Learning.
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DOI:
10.1007/s12021-022-09608-0
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发表时间:
2023-01
期刊:
影响因子:
3
通讯作者:
--
中科院分区:
医学4区
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--
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功能微电路模拟神经元的协调活动,在生理计算和行为中发挥重要作用。大多数现有的学习微电路结构的方法都是基于相关性的,并且通常会生成无法区分直接关联和间接关联的密集微电路。我们把微电路结构学习作为一个马尔可夫毯发现问题,并提出贝叶斯一致性分析(BCA),它利用贝叶斯网络架构称为贝叶斯网络与逆树结构,以有效地和有效地检测高维神经活动数据的马尔可夫毯。BCA在模拟数据上实现了平衡的灵敏度和特异性。对于现实世界的前外侧运动皮层研究,BCA确定了预测试验类型的微电路亚型,准确度为0.92。BCA是微电路结构学习的有力方法。
Functional microcircuits model the coordinated activity of neurons and play an important role in physiological computation and behaviors. Most existing methods to learn microcircuit structures are correlation-based and often generate dense microcircuits that cannot distinguish between direct and indirect association. We treat microcircuit structure learning as a Markov blanket discovery problem and propose Bayesian Coherence Analysis (BCA) which utilizes a Bayesian network architecture called Bayesian network with inverse-tree structure to efficiently and effectively detect Markov blankets for high-dimensional neural activity data. BCA achieved balanced sensitivity and specificity on simulated data. For the real-world anterior lateral motor cortex study, BCA identified microcircuit subtypes that predicted trial types with an accuracy of 0.92. BCA is a powerful method for microcircuit structure learning.
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