Serum neurotensin (NT) is increased in psoriasis and NT induces vascular endothelial growth factor release from human mast cells.
Serum neurotensin (NT) is increased in psoriasis and NT induces vascular endothelial growth factor release from human mast cells.
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牛皮癣中血清神经素（NT）增加，NT诱导人类肥大细胞释放血管内皮生长因子。
DOI：
10.1111/j.1365-2133.2012.10843.x
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发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Theoharides TC
中科院分区：
文献类型：
--
作者：
Vasiadi M;Therianou A;Alysandratos KD;Katsarou-Katsari A;Petrakopoulou T;Theoharides A;Papadavid E;Stavrianeas N;Antoniou C;Kalogeromitros D;Theoharides TC
Psoriasis involves skin inflammation that often worsens with stress, but the mechanism of this effect remains obscure. We have shown that corticotrophin- releasing hormone (CRH) is increased in the serum of patients with psoriasis. A peptide, neurotensin (NT), can trigger skin histamine release and augment the ability of CRH to increase skin vascular permeability. To investigate the serum level of NT, and the expression of genes for NT and NT receptor-1 (NTR-1) in lesional and nonlesional skin of patients with psoriasis, compared with normal controls. Also, to study the effect of NT on human mast cell release of vascular endothelial growth factor (VEGF), which is increased in psoriasis skin. Serum was obtained from patients with psoriasis (n = 56) and controls (n = 33); NT levels were measured with the Milliplex microbead assay. Biopsies were obtained from the lesional and nonlesional skin of patients with chronic plaque psoriasis (n = 40), who had not received any treatment for at least 15 days and were free of any systemic inflammatory diseases. Control skin samples were obtained from healthy subjects (n = 30). Expression of genes for NT and NTR-1 in the skin was evaluated by quantitative reverse transcriptase–polymerase chain reaction. LAD2 human mast cells were stimulated by NT (1 μmol L−1) for 24 h and VEGF was measured by enzyme-linked immunosorbent assay. Serum NT was increased in patients with psoriasis, while expression of genes for NT and NTR-1 in lesional skin was decreased compared with controls. NT induced VEGF release from mast cells and was augmented by interleukin-33. NT may play a role in psoriasis pathogenesis and its worsening by stress, at least in part through activation of skin mast cells.
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DOI：
10.1097/med.0b013e3283419052
发表时间：
2011-02-01
影响因子：
3.2
作者：
Mustain, W. Conan;Rychahou, Piotr G.;Evers, B. Mark
通讯作者：
Evers, B. Mark
DOI：
10.1159/000234057
发表时间：
1986-01-01
期刊：
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY
影响因子：
--
作者：
COCHRANE, DE;BOUCHER, W;BIBB, P
通讯作者：
BIBB, P
影响因子：
10.3
作者：
Amatya, B.;El-Nour, H.;Nordlind, K.
通讯作者：
Nordlind, K.
DOI：
10.1073/pnas.0602210103
发表时间：
2006-05-16
影响因子：
11.1
作者：
Donelan, Jill;Boucher, William;Theoharides, Theoharis C.
通讯作者：
Theoharides, Theoharis C.
DOI：
10.1073/pnas.1000803107
发表时间：
2010-03-02
影响因子：
11.1
作者：
Theoharides, Theoharis C.;Zhang, Bodi;Conti, Pio
通讯作者：
Conti, Pio