Self-rated health and C-reactive protein in young adults.
Self-rated health and C-reactive protein in young adults.
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DOI：
10.1016/j.bbi.2013.10.020
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发表时间：
2014-02
影响因子：
15.1
通讯作者：
Bondy, Carmen L.
中科院分区：
文献类型：
--
作者：
Shanahan, Lilly;Bauldry, Shawn;Freeman, Jason;Bondy, Carmen L.
关键词：
健康状况不佳（SRH）和炎症、发病率和死亡率升高与中老年人密切相关。关于青年期SRH升高的炎症相关性以及这些联系是否因性别而异，我们知之甚少。数据来自国家青少年健康纵向研究。在第四波，24-34岁的年轻人报告了他们的性健康和生殖健康、急性和慢性疾病以及与健康有关的社会人口和心理特征。经过培训的现场工作人员评估药物使用，BMI，腰围，并收集血点，从中检测高灵敏度CRP（hs-CRP）。本分析的样本量为N= 13，236。描述性和双变量分析揭示了SRH和hs-CRP之间的分级相关性：SRH评分较低与hs-CRP > 3 mg/L和hs-CRP平均水平较高的参与者比例较高相关。当急性和慢性疾病、药物使用和健康行为被考虑在内时，SRH和hs-CRP之间的关联仍然显着。当考虑到BMI时，女性SRH和hs-CRP之间的关联完全减弱;男性SRH和hs-CRP之间的关联很小，但仍显着。在年轻人中，不良的SRH和升高的hs-CRP相关，调整其他健康状况指标，药物使用和健康行为。在男性中，SRH提供了与BMI无关的hs-CRP升高的信息。在女性中，与SRH相比，BMI可能是全球健康和促炎影响的更好替代指标。
Poor self-rated health (SRH) and elevated inflammation and morbidity and mortality are robustly associated in middle- and older-aged adults. Less is known about SRH-elevated inflammation associations during young adulthood and whether these linkages differ by sex. Data came from the National Longitudinal Study of Adolescent Health. At Wave IV, young adults aged 24–34 reported their SRH, acute and chronic illnesses, and sociodemographic and psychological characteristics relevant to health. Trained fieldworkers assessed medication use, BMI, waist circumference, and also collected bloodspots from which high-sensitivity CRP (hs-CRP) was assayed. The sample size for the present analyses was N=13,236. Descriptive and bivariate analyses revealed a graded association between SRH and hs-CRP: Lower ratings of SRH were associated with a higher proportion of participants with hs-CRP > 3 mg/L and higher mean levels of hs-CRP. Associations between SRH and hs-CRP remained significant when acute and chronic illnesses, medication use, and health behaviors were taken into account. When BMI was taken into account, the association between SRH and hs-CRP association fully attenuated in females; a small, but significant association between SRH and hs-CRP remained in males. Poor SRH and elevated hs-CRP are associated in young adults, adjusting for other health status measures, medication use, and health behavior. In males, SRH provided information about elevated hs-CRP that was independent of BMI. In females, BMI may be a better surrogate indicator of global health and pro-inflammatory influences compared to SRH.
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影响因子：
5
作者：
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