Effect of cigarette smoking on HIV acquisition, progression, and mortality.
Effect of cigarette smoking on HIV acquisition, progression, and mortality.
复制标题
DOI：
10.1521/aeap.2009.21.3_supp.28
复制
发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Kirk GD
中科院分区：
文献类型：
--
作者：
Marshall MM;McCormack MC;Kirk GD
与普通人群相比，吸烟在艾滋病毒感染者中更为常见。然而，目前尚不清楚吸烟是否会改变艾滋病毒感染的自然史，或者在艾滋病毒感染的情况下是否会发生与吸烟有关的独特健康后果。在这篇文章中，我们回顾了吸烟对艾滋病毒感染、艾滋病毒发展为艾滋病以及死亡率的影响。虽然在评估的研究人群中存在显著的异质性，但我们几乎没有发现吸烟增加获得艾滋病毒风险的证据。虽然有两项研究发现吸烟与CD4细胞计数下降更快有关，但大多数数据表明吸烟不会加速临床艾滋病的进展。最一致的发现是吸烟者呼吸道感染的风险增加。虽然吸烟对艾滋病相关死亡率没有影响，但与全因死亡率相关的研究结果尚不确定。由于HAART后时期慢性非艾滋病结局的增加，吸烟可能是艾滋病毒感染人群发病率和死亡率的一个越来越重要的因素。未来的调查的生物学和临床影响的吸烟，并采取预防措施，以减少沉重的负担，在个人与艾滋病毒是必要的。
Cigarette smoking is more common among those with HIV compared to the general population. However, it remains unclear whether smoking alters the natural history of HIV infection or if unique health consequences related to smoking occur in the context of HIV. In this article, we review the literature on the effect of smoking on acquisition of HIV, progression of HIV to AIDS, and mortality. While there was significant heterogeneity in the study populations evaluated, we found little evidence that cigarette smoking increases the risk for acquiring HIV. Although two studies observed that smoking was associated with more rapid CD4 cell count declines, most data suggest that smoking does not accelerate progression to clinical AIDS. The most consistent finding was an increased risk for respiratory infections in smokers. While no effect of smoking was seen with AIDS-related mortality, findings related to all-cause mortality were inconclusive. Due to an increase in chronic non-AIDS outcomes in the post-HAART era, smoking is likely an increasingly important contributor to morbidity and mortality in HIV-infected populations. Future investigation of the biological and clinical effects of smoking, and of preventive approaches to reduce the heavy burden, in individuals with HIV is warranted.
登录
查看更多内容
影响因子：
4.7
作者：
Burkhalter, JE;Springer, CM;Rapkin, BD
通讯作者：
Rapkin, BD
影响因子：
3.8
作者：
ROYCE, RA;LUCKMANN, RS;WINKELSTEIN, W
通讯作者：
WINKELSTEIN, W
DOI：
10.1097/00126334-200306012-00003
发表时间：
2003-06-01
影响因子：
3.6
作者：
Mack, KA;Ory, MG
通讯作者：
Ory, MG
影响因子：
11.8
作者：
Kirk, Gregory D.;Merlo, Christian;Engels, Eric A.
通讯作者：
Engels, Eric A.
DOI：
10.1177/140349489402200309
发表时间：
1994-09-01
期刊：
SCANDINAVIAN JOURNAL OF SOCIAL MEDICINE
影响因子：
--
作者：
ESKILD, A;PETERSEN, G
通讯作者：
PETERSEN, G