Live bird markets of Bangladesh: H9N2 viruses and the near absence of highly pathogenic H5N1 influenza.
Live bird markets of Bangladesh: H9N2 viruses and the near absence of highly pathogenic H5N1 influenza.
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DOI：
10.1371/journal.pone.0019311
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发表时间：
2011-04-26
期刊：
影响因子：
3.7
通讯作者：
Webster RG
中科院分区：
文献类型：
--
作者：
Negovetich NJ;Feeroz MM;Jones-Engel L;Walker D;Alam SM;Hasan K;Seiler P;Ferguson A;Friedman K;Barman S;Franks J;Turner J;Krauss S;Webby RJ;Webster RG
孟加拉国的禽流感监测一直是被动的，依靠家禽养殖户报告疑似高致病性H5N1流感暴发。在此，介绍了以活禽市场为重点的积极监测工作的结果。活禽市场的禽鸟感染流感的流行率为23.0%，与其他国家家禽市场的流行率相似。几乎所有分离株（94%）为非致病性H9N2亚型，但也观察到H1N2、H1N3、H3N6、H4N2、H5N1和H10N7亚型的病毒。在监测样本中观察到高致病性h5n1亚型病毒的流行率极低（0.08%），我们认为目前孟加拉国零售家禽市场中人类感染的风险可以忽略不计。然而，H9亚型的高流行率及其与高致病性h5n1亚型的潜在相互作用，即宿主发病率的重新组合和衰减，突出了对家禽市场进行积极监测的重要性。
Avian influenza surveillance in Bangladesh has been passive, relying on poultry farmers to report suspected outbreaks of highly pathogenic H5N1 influenza. Here, the results of an active surveillance effort focusing on the live-bird markets are presented. Prevalence of influenza infection in the birds of the live bird markets is 23.0%, which is similar to that in poultry markets in other countries. Nearly all of the isolates (94%) were of the non-pathogenic H9N2 subtype, but viruses of the H1N2, H1N3, H3N6, H4N2, H5N1, and H10N7 subtypes were also observed. The highly pathogenic H5N1-subtype virus was observed at extremely low prevalence in the surveillance samples (0.08%), and we suggest that the current risk of infection for humans in the retail poultry markets in Bangladesh is negligible. However, the high prevalence of the H9 subtype and its potential for interaction with the highly pathogenic H5N1-subtype, i.e., reassortment and attenuation of host morbidity, highlight the importance of active surveillance of the poultry markets.
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