A reanalysis of cancer mortality in Canadian nuclear workers (1956-1994) based on revised exposure and cohort data.
A reanalysis of cancer mortality in Canadian nuclear workers (1956-1994) based on revised exposure and cohort data.
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DOI：
10.1038/bjc.2013.592
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发表时间：
2014-01-07
影响因子：
8.8
通讯作者：
Thompson, P. A.
中科院分区：
文献类型：
--
作者：
Zablotska, L. B.;Lane, R. S. D.;Thompson, P. A.
一项针对15个国家的核工人的研究报告称，除白血病外，所有癌症与辐射相关的风险都显著增加，加拿大的数据是综合结果背后的主要因素。我们分析了更新后的加拿大队列的死亡率（1956-1994），并提供了修订后的风险估计。研究人员检索了就业记录，以核实和修改暴露数据，并恢复缺失的社会经济地位。使用泊松回归估计每西弗记录辐射剂量的过量相对风险（ERR/Sv）和95%置信区间（ci）。发现实体癌的剂量反应存在显著的异质性（P=0.02）， 3088名早期（1956-1964）加拿大原子能有限公司（AECL）工人的辐射风险显著增加（ERR/Sv=7.87, 95% CI: 1.88, 19.5），三家核电站公司和1964年后AECL工作的42228名工人没有辐射风险的证据（ERR/Sv= - 1.20, 95% CI: < - 1.47, 2.39）。早期AECL工人白血病的辐射风险为负，其他工人无显著增加。在对氚和伽马剂量分别进行的分析中，没有证据表明氚暴露会增加风险。所有工人的死亡率都低于一般人群。早期AECL工作人员的风险显著增加最有可能是由于AECL剂量记录未完全转移到国家剂量登记处。对其余加拿大核工人（93.2%）的分析没有提供风险增加的证据，但风险估计与构成辐射防护标准基础的估计是一致的。研究结果表明，修订后的加拿大队列排除了早期AECL工作人员，可能会对15个国家对除白血病外所有癌症辐射相关风险的综合风险估计产生重要影响，因为这大大减少了点估计的大小及其重要性。
A 15-country study of nuclear workers reported significantly increased radiation-related risks of all cancers excluding leukaemia, with Canadian data a major factor behind the pooled results. We analysed mortality (1956–1994) in the updated Canadian cohort and provided revised risk estimates. Employment records were searched to verify and revise exposure data and to restore missing socioeconomic status. Excess relative risks per sievert (ERR/Sv) of recorded radiation dose and 95% confidence intervals (CIs) were estimated using Poisson regression. A significant heterogeneity of the dose–response for solid cancer was identified (P=0.02), with 3088 early (1956–1964) Atomic Energy of Canada Limited (AECL) workers having a significant increase (ERR/Sv=7.87, 95% CI: 1.88, 19.5), and no evidence of radiation risk for 42 228 workers employed by three nuclear power plant companies and post-1964 AECL (ERR/Sv=−1.20, 95% CI: <−1.47, 2.39). Radiation risks of leukaemia were negative in early AECL workers and non-significantly increased in other workers. In analyses with separate terms for tritium and gamma doses, there was no evidence of increased risk from tritium exposure. All workers had mortality lower than the general population. Significantly increased risks for early AECL workers are most likely due to incomplete transfer of AECL dose records to the National Dose Registry. Analyses of the remainder of the Canadian nuclear workers (93.2%) provided no evidence of increased risk, but the risk estimate was compatible with estimates that form the basis of radiation protection standards. Study findings suggest that the revised Canadian cohort, with the exclusion of early AECL workers, would likely have an important effect on the 15-country pooled risk estimate of radiation-related risks of all cancer excluding leukaemia by substantially reducing the size of the point estimate and its significance.
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影响因子：
5
作者：
HOWE, GR;CHIARELLI, AM;LINDSAY, JP
通讯作者：
LINDSAY, JP
DOI：
10.1016/0010-4809(81)90004-5
发表时间：
1981-01-01
期刊：
COMPUTERS AND BIOMEDICAL RESEARCH
影响因子：
--
作者：
HOWE, GR;LINDSAY, J
通讯作者：
LINDSAY, J
影响因子：
3.4
作者：
Cardis, E.;Vrijheid, M.;Veress, K.
通讯作者：
Veress, K.
影响因子：
3.4
作者：
Preston, D. L.;Krestinina, L. Yu;Gilbert, E. S.
通讯作者：
Gilbert, E. S.
影响因子：
8.4
作者：
Ashmore, JP;Krewski, D;Zielinski, JM
通讯作者：
Zielinski, JM