A history of asthma may be associated with grandparents' exposures to stress and cigarette smoking.
A history of asthma may be associated with grandparents' exposures to stress and cigarette smoking.
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DOI：
10.3389/ftox.2023.1253442
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发表时间：
2023
影响因子：
--
通讯作者：
Suderman, Matthew
中科院分区：
文献类型：
--
作者：
Golding, Jean;Tunstall, Holly;Gregory, Steve;Granell, Raquel;Dodd, James W.;Iles-Caven, Yasmin;Watkins, Sarah;Suderman, Matthew
关键词：
简介：在人类流行病学研究中，已经证明了祖父母在童年时期的接触与孙辈的结果之间的关联。一些研究已经评估了哮喘是否与吸烟有关，但到目前为止，结果好坏参半。 材料和方法：在这项研究中，我们使用了四代：（F0曾祖父母，F1祖父母，F2父母，雅芳父母和儿童纵向研究（ALSPAC）的F3研究儿童），以确定是否有证据表明F2或F3代哮喘与儿童期严重创伤暴露之间存在关联，和/或或F0代和F1代祖母和祖父在青春期主动吸烟，或F0代或F1代祖母在怀孕期间吸烟史。 结果如下：我们已经证明：a）在祖父母童年时期，F1祖父母的父母死亡的压力与F3代哮喘风险增加有关，特别是如果涉及的祖父母是父亲的祖母; B）如果F0代或F1代的祖父母在青春期吸烟（即< 17岁），他们在F2和F3代的孙辈更有可能有哮喘史; c）父亲的F1祖母在怀孕期间吸烟与她的F3孙辈在7岁时的哮喘有关;（d）祖母的孙子和孙女在青春期吸烟和在怀孕期间吸烟的结果之间存在差异。e）与仅在P < 0.10时添加与哮喘相关的人口统计学因素（如社会阶层）相比，将所有个体暴露变量添加到不同分析中通常会显著提高拟合优度;当所有四个暴露变量合并到一个模型中时，尤其如此，表明它们之间可能存在协同效应。 讨论内容：我们已经证明了祖父母接触的所有四种类型与孙辈的哮喘相关，因此结果既取决于是否涉及男性或女性系，也取决于孙辈的性别。值得注意的是，祖母特别参与了许多协会。我们强调这些是探索性分析，哮喘诊断标准可能会随着时间的推移而改变，并且可能在世代之间不一致，并且结果应该在其他队列中进行测试。
Introduction: Within human epidemiological studies, associations have been demonstrated between grandparental exposures during childhood and grandchildren’s outcomes. A few studies have assessed whether asthma has ancestral associations with exposure to cigarette smoking, but results have been mixed so far. Material and methods: In this study we used four generations: (F0 great-grandparents, F1 grandparents, F2 parents, F3 study children) of the Avon Longitudinal Study of Parents and Children (ALSPAC) to determine whether there is evidence of associations between asthma in generations F2 or F3 and exposures to severe trauma in childhood and/or active cigarette smoking during the adolescence of grandmothers and grandfathers in generations F0 and F1 respectively, or of a history of a F0 or F1 grandmother smoking during pregnancy. Results: We have shown that: a) stress exemplified by the death of a F1 grandparent’s parent during the grandparents’ childhood was associated with increased risk of asthma in generation F3, especially if the grandparent involved was the paternal grandmother; b) if the grandparents of generations F0 or F1 smoked during adolescence (i.e. < 17 years), their grandchildren in generations F2 and F3 were more likely to have a history of asthma; c) paternal F1 grandmother’s smoking in pregnancy was associated with her F3 grandchild’s asthma at age 7; d) There were differences between the results for the grandsons and granddaughters of the paternal grandmother with exposure to smoking in adolescence and with smoking in pregnancy. e) The addition of all of the individual exposure variables to the different analyses often provided a considerable increase in goodness of fit compared with only adding demographic factors associated with asthma at P < 0.10 such as social class; this was particularly true when all four exposure variables were combined in one model, suggesting possible synergistic effects between them. Discussion: We have shown associations between all four types of exposure to the grandparents to be associated with asthma in the grandchildren, such that the results both depended on whether the male or female line was involved, and the sex of the grandchildren. It was notable that the paternal grandmother was particularly involved in many of the associations. We emphasize that these are exploratory analyses, that asthma diagnostic criteria likely changed over time and may not be consistent between generations, and that the results should be tested in other cohorts.
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DOI：
10.1016/j.jaci.2016.12.002
发表时间：
2017-02
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Arshad SH;Karmaus W;Zhang H;Holloway JW
通讯作者：
Holloway JW
影响因子：
4.4
作者：
Braback, Lennart;Lodge, Caroline J.;Forsberg, Bertil
通讯作者：
Forsberg, Bertil
影响因子：
--
作者：
Northstone, Kate;Lewcock, Melanie;Wells, Nicholas
通讯作者：
Wells, Nicholas
影响因子：
5.2
作者：
Pembrey, ME;Bygren, LO;Golding, J
通讯作者：
Golding, J
影响因子：
10
作者：
Mahon GM;Koppelman GH;Vonk JM
通讯作者：
Vonk JM