From Initiators to Effectors: Roadmap Through the Intestine During Encounter of Toxoplasma gondii With the Mucosal Immune System.
From Initiators to Effectors: Roadmap Through the Intestine During Encounter of Toxoplasma gondii With the Mucosal Immune System.
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DOI：
10.3389/fcimb.2020.614701
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发表时间：
2020
影响因子：
5.7
通讯作者：
Denkers EY
中科院分区：
文献类型：
--
作者：
Snyder LM;Denkers EY
胃肠道是许多病原体的主要入口，包括原生动物寄生虫弓形虫。全世界有数十亿人感染了T。弓形虫在他们的生活中的某个时候，对绝大多数人来说，这导致了中枢神经系统的潜伏感染。宿主抵抗弓形虫的第一道防线位于肠粘膜内。肠上皮、上皮内淋巴细胞和固有层细胞的反应的适当协调导致控制急性感染的炎症反应。在某些情况下，感染会导致肠道细菌生态失调和免疫介导的组织损伤。在这里，我们讨论了微生物群，上皮细胞以及肠粘膜中诱导保护性免疫的先天性和适应性免疫细胞之间的复杂相互作用，有时会转变为T.刚地虫遇到肠道组织。
The gastrointestinal tract is a major portal of entry for many pathogens, including the protozoan parasite Toxoplasma gondii. Billions of people worldwide have acquired T. gondii at some point in their life, and for the vast majority this has led to latent infection in the central nervous system. The first line of host defense against Toxoplasma is located within the intestinal mucosa. Appropriate coordination of responses by the intestinal epithelium, intraepithelial lymphocytes, and lamina propria cells results in an inflammatory response that controls acute infection. Under some conditions, infection elicits bacterial dysbiosis and immune-mediated tissue damage in the intestine. Here, we discuss the complex interactions between the microbiota, the epithelium, as well as innate and adaptive immune cells in the intestinal mucosa that induce protective immunity, and that sometimes switch to inflammatory pathology as T. gondii encounters tissues of the gut.
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影响因子：
30.3
作者：
Benson A;Pifer R;Behrendt CL;Hooper LV;Yarovinsky F
通讯作者：
Yarovinsky F
影响因子：
30.3
作者：
Burger E;Araujo A;López-Yglesias A;Rajala MW;Geng L;Levine B;Hooper LV;Burstein E;Yarovinsky F
通讯作者：
Yarovinsky F
DOI：
10.1084/jem.20020258
发表时间：
2002-06-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Barragan A;Sibley LD
通讯作者：
Sibley LD
DOI：
10.4049/jimmunol.1501137
发表时间：
2015-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cohen SB;Denkers EY
通讯作者：
Denkers EY
影响因子：
3.4
作者：
Barragan, A;Brossier, F;Sibley, LD
通讯作者：
Sibley, LD