Serotonergic, brain volume and attentional correlates of trait anxiety in primates.
Serotonergic, brain volume and attentional correlates of trait anxiety in primates.
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DOI：
10.1038/npp.2014.324
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发表时间：
2015-05
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影响因子：
--
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特质焦虑是情感障碍发展和维持的危险因素，深入了解潜在的大脑机制对于改善治疗和预防策略至关重要。在非人类灵长类动物中进行转化研究，可以进行有针对性的神经化学和遗传操作，鉴于它们在涉及特质焦虑的大脑区域与人类的神经解剖学相似性，这一研究至关重要。因此，我们的特点是在绒猴的特质样焦虑的肾上腺素能和区域脑容量相关。低焦虑和高焦虑的动物通过对人类入侵者的行为反应来识别，已知人类入侵者对抗焦虑药物治疗敏感。杏仁核内的细胞外5-羟色胺水平测定与体内微透析，在基线和响应挑战与选择性5-羟色胺再摄取抑制剂，西酞普兰。通过结构磁共振成像评估局部脑体积。安纳托里亚人表现出持续的，长期的恐惧反应，人类入侵者和模型蛇，以及持续的注意力（警惕），以新的线索，在与不可预测的威胁。在神经方面，高度焦虑的绒猴表现出杏仁核5-羟色胺水平降低，与之紧密相连的前额叶区域（背侧前扣带皮层）体积变小。这些发现突出了绒猴和人类的特质焦虑之间的行为和神经相似性，并为进一步研究导致情感障碍的脆弱性和恢复力的过程奠定了基础。
Trait anxiety is a risk factor for the development and maintenance of affective disorders, and insights into the underlying brain mechanisms are vital for improving treatment and prevention strategies. Translational studies in non-human primates, where targeted neurochemical and genetic manipulations can be made, are critical in view of their close neuroanatomical similarity to humans in brain regions implicated in trait anxiety. Thus, we characterised the serotonergic and regional brain volume correlates of trait-like anxiety in the marmoset monkey. Low- and high-anxious animals were identified by behavioral responses to a human intruder that are known to be sensitive to anxiolytic drug treatment. Extracellular serotonin levels within the amygdala were measured with in vivo microdialysis, at baseline and in response to challenge with the selective serotonin reuptake inhibitor, citalopram. Regional brain volume was assessed by structural magnetic resonance imaging. Anxious individuals showed persistent, long-term fearful responses to both a human intruder and a model snake, alongside sustained attention (vigilance) to novel cues in a context associated with unpredictable threat. Neurally, high-anxious marmosets showed reduced amygdala serotonin levels, and smaller volumes in a closely connected prefrontal region, the dorsal anterior cingulate cortex. These findings highlight behavioral and neural similarities between trait-like anxiety in marmosets and humans, and set the stage for further investigation of the processes contributing to vulnerability and resilience to affective disorders.
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影响因子：
25
作者：
Nikolova, Yuliya S.;Koenen, Karestan C.;Galea, Sandro;Wang, Chiou-Miin;Seney, Marianne L.;Sibille, Etienne;Williamson, Douglas E.;Hariri, Ahmad R.
通讯作者：
Hariri, Ahmad R.
影响因子：
2.6
作者：
Giuliani, Nicole R.;Drabant, Emily M.;Gross, James J.
通讯作者：
Gross, James J.
在大鼠和人类中持续的恐惧：恐惧与焦虑中的杏仁核的作用。
DOI：
10.1038/npp.2009.109
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
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影响因子：
3.7
作者：
Machado, Christopher J.;Bachevalier, Jocelyne
通讯作者：
Bachevalier, Jocelyne
影响因子：
2.5
作者：
Barros, M;Boere, V;Tomaz, C
通讯作者：
Tomaz, C