Directed information exchange between cortical layers in macaque V1 and V4 and its modulation by selective attention.
Directed information exchange between cortical layers in macaque V1 and V4 and its modulation by selective attention.
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猕猴V1和V4中的皮层层之间的定向信息交换及其通过选择性注意的调制。
DOI：
10.1073/pnas.2022097118
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发表时间：
2021-03-23
影响因子：
11.1
通讯作者：
Thiele A
中科院分区：
文献类型：
--
作者：
Ferro D;van Kempen J;Boyd M;Panzeri S;Thiele A
注意被认为是通过改变特定频带内皮层区域之间的交流来调节感觉加工的。利用局部场电位记录，我们通过猕猴V1和V4的层流记录测试了这一影响模型。注意力出乎意料地调节了沟通。在V1中，除了颗粒到超颗粒的相互作用外，它减少了跨频谱频率的通信。在V4中，它增加了跨所有频谱频率的通信。关键是，注意力增加了所有频段的V1-V4前馈通信，减少了低频频段的V4-V1反馈通信，增加了β和γ反馈通信。这些发现挑战了现有的前馈和反馈相互作用的频率特异性理论。实现行为目标需要通过皮质层和皮质区域整合感觉和认知信息。这个计算是如何执行的仍然未知。利用局部场电位记录和频谱解析条件格兰杰因果关系（cGC）分析，我们绘制了猕猴大脑V1区和V4区内部和之间皮层层之间的视觉信息流及其注意调制。刺激诱导的V1层间信息流向上主导，将信息输送到核上皮层输出层。在V4内，信息流以粒状向粒状上层为主，粒状上层与粒状下层之间的相互作用为主。低频跨区域通信从V4到V1较强，层特异性较小。在前馈v1 - v4方向上，伽马波段通信更强。除了颗粒层与粒上层的相互作用外，对V1感受野的关注减少了所有V1层之间的交流。V4内部的通信以及从V1到V4的通信随着所有频率的关注而增加。虽然从V4到V1的通信在较低频段（4至25 Hz）更强，但在所有被调查的频率中，注意力调节了从V4到V1的cgc。我们的数据显示，自上而下的认知过程导致皮质区域内的交流减少，所有频段的前馈交流增加，伽马波段反馈交流增加。
Attention is thought to modulate sensory processing by changing communication between cortical areas within specific frequency bands. Using local field potential recordings, we tested this influential model through laminar recordings in macaque V1 and V4. Attention modulated communication unexpectedly. In V1, it decreased communication across spectral frequencies except for granular-to-supragranular interactions. In V4, it increased communication across all spectral frequencies. Critically, attention increased V1–V4 feedforward communication across all frequency bands, decreased V4–V1 feedback communication in low-frequency bands, and increased beta and gamma feedback communication. These findings challenge existing theories of frequency specificity of feedforward and feedback interactions. Achieving behavioral goals requires integration of sensory and cognitive information across cortical laminae and cortical regions. How this computation is performed remains unknown. Using local field potential recordings and spectrally resolved conditional Granger causality (cGC) analysis, we mapped visual information flow, and its attentional modulation, between cortical layers within and between macaque brain areas V1 and V4. Stimulus-induced interlaminar information flow within V1 dominated upwardly, channeling information toward supragranular corticocortical output layers. Within V4, information flow dominated from granular to supragranular layers, but interactions between supragranular and infragranular layers dominated downwardly. Low-frequency across-area communication was stronger from V4 to V1, with little layer specificity. Gamma-band communication was stronger in the feedforward V1-to-V4 direction. Attention to the receptive field of V1 decreased communication between all V1 layers, except for granular-to-supragranular layer interactions. Communication within V4, and from V1 to V4, increased with attention across all frequencies. While communication from V4 to V1 was stronger in lower-frequency bands (4 to 25 Hz), attention modulated cGCs from V4 to V1 across all investigated frequencies. Our data show that top-down cognitive processes result in reduced communication within cortical areas, increased feedforward communication across all frequency bands, and increased gamma-band feedback communication.
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影响因子：
16.2
作者：
Bosman CA;Schoffelen JM;Brunet N;Oostenveld R;Bastos AM;Womelsdorf T;Rubehn B;Stieglitz T;De Weerd P;Fries P
通讯作者：
Fries P
影响因子：
16.2
作者：
Bastos AM;Usrey WM;Adams RA;Mangun GR;Fries P;Friston KJ
通讯作者：
Friston KJ
DOI：
10.1073/pnas.1011284108
发表时间：
2011-07-05
影响因子：
11.1
作者：
Buffalo, Elizabeth A.;Fries, Pascal;Desimone, Robert
通讯作者：
Desimone, Robert
影响因子：
64.8
作者：
Briggs, Farran;Mangun, George R.;Usrey, W. Martin
通讯作者：
Usrey, W. Martin
影响因子：
2.9
作者：
Feldman H;Friston KJ
通讯作者：
Friston KJ