Attentional stimulus selection through selective synchronization between monkey visual areas.

Attentional stimulus selection through selective synchronization between monkey visual areas.
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DOI:
10.1016/j.neuron.2012.06.037
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发表时间:
2012-09-06
期刊:
影响因子:
16.2
通讯作者:
Fries P
Fries P
中科院分区:
医学1区
文献类型:
--
作者:
Bosman CA;Schoffelen JM;Brunet N;Oostenveld R;Bastos AM;Womelsdorf T;Rubehn B;Stieglitz T;De Weerd P;Fries P

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神经网络的一个核心主题是汇聚,它将多个输入神经元连接到一个目标神经元。在视觉皮层中,汇聚使目标神经元对复杂刺激产生反应。然而,汇聚通常会将多个刺激发送到一个目标,必须选择与行为相关的刺激。我们使用了两种刺激,激活不同的皮质脑电图V1位点,并且两种刺激对皮质脑电图V4位点的激活强度相同。当其中一种刺激激活一个V1位点时,它与V4在伽马频段(60 - 80赫兹)同步。当两种刺激激活两个V1位点时,主要是相关的那个与V4在伽马频段同步。伽马活动的频段显示出大量重叠,包含区域间相干性的频段。相关的V1位点的伽马峰值频率比不相关的V1位点高2 - 3赫兹,比V4高4 - 6赫兹。伽马介导的区域间影响主要是从V1指向V4。我们提出,选择性同步使相关输入有效,从而调节有效连接性。
A central motif in neuronal networks is convergence, linking several input neurons to one target neuron. In visual cortex, convergence renders target neurons responsive to complex stimuli. Yet, convergence typically sends multiple stimuli to a target, and the behaviorally relevant stimulus must be selected. We used two stimuli, activating separate electrocorticographic V1 sites, and both activating an electrocorticographic V4 site equally strongly. When one of those stimuli activated one V1 site, it gamma-synchronized (60–80 Hz) to V4. When the two stimuli activated two V1 sites, primarily the relevant one gamma-synchronized to V4. Frequency bands of gamma activities showed substantial overlap containing the band of inter-areal coherence. The relevant V1 site had its gamma peak frequency 2–3 Hz higher than the irrelevant V1 site, and 4–6 Hz higher than V4. Gamma-mediated inter-areal influences were predominantly directed from V1 to V4. We propose that selective synchronization renders relevant input effective, thereby modulating effective connectivity.
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