Within-Family Effects of Smoking during Pregnancy on ADHD: the Importance of Phenotype.
Within-Family Effects of Smoking during Pregnancy on ADHD: the Importance of Phenotype.
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DOI：
10.1007/s10802-017-0320-7
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发表时间：
2018-05
影响因子：
3.6
通讯作者：
Knopik VS
中科院分区：
文献类型：
--
作者：
Marceau K;Cinnamon Bidwell L;Karoly HC;Evans AS;Todorov AA;Palmer RH;Heath AC;Knopik VS
我们试图使用基于传统的精神疾病诊断和统计手册第4版（DSM-IV）症状和ADHD症状和正常行为量表（SWAN）的优势和劣势的结构化访谈来测试怀孕期间吸烟（SDP）和注意缺陷多动障碍（ADHD）症状的家庭内和家庭间的关联，这是一种基于人群的测量方法，它源于这样一种概念，即ADHD诊断存在于规范行为连续体的极端，包括注意力和活动的高于和低于平均水平的表现。我们使用了同胞比较的方法，在173个家庭的样本，包括7-16岁的兄弟姐妹（52%男性）从美国的密苏里州，其中母亲吸烟在一个怀孕期间，但不是其他。有一个家庭内的影响，在怀孕期间吸烟的天鹅多动/冲动和天鹅总ADHD行为。SDP和DSM-IV为基础的ADHD症状维度以及SWAN注意力不集中之间的关联被解释为家族性混淆。这些研究结果表明，SDP对ADHD多动/冲动行为的增加产生了潜在的因果影响，并且当多动/冲动在人群中进行更规范的评估时，这种SDP效应最好被捕获，而不是通过DSM症状专门评估有问题的行为。因此，SDP对ADHD症状维度的任何潜在因果影响可能仅限于多动/冲动行为，而不是注意力不集中，并且规范的、基于非DSM-IV的行为测量可以提供对SDP-ADHD症状关联机制的更灵敏的测试，特别是在非临床样本中。
We sought to test within- and between- family associations of smoking during pregnancy (SDP) and attention deficit-hyperactivity disorder (ADHD) symptoms using a structured interview based on the conventional Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) symptoms and the Strengths and Weaknesses of ADHD-Symptoms and Normal-Behavior (SWAN) scale, which is a population based measure that grew out of the notion that an ADHD diagnosis exists on the extreme end of a continuum of normative behaviors and includes both above- and below- average performance on attention and activity. We used a sibling-comparison approach in a sample of 173 families including siblings aged 7-16 years (52% male) drawn from the state of Missouri, USA, wherein mothers smoked during one pregnancy but not the other. There was a within-family effect of smoking during pregnancy on SWAN hyperactivity/impulsivity and SWAN total ADHD behaviors. The associations between SDP and DSM-IV-based ADHD symptom dimensions as well as SWAN inattention were explained by familial confounds. These findings suggest that SDP exerts a potentially causal effect on increased ADHD hyperactive/impulsive behaviors and that this SDP effect is best captured when hyperactivity/impulsivity is assessed more normatively across the population, rather than specifically assessing problematic behaviors via DSM symptoms. Thus, any potentially causal effect of SDP on ADHD symptom dimensions may be restricted to hyperactive/impulsive behaviors rather than inattention, and normative, non-DSM-IV based behavioral measures may provide a more sensitive test of mechanisms of SDP-ADHD symptom associations, particularly in non-clinical samples.
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DOI：
10.3390/ijerph110707261
发表时间：
2014-07-16
影响因子：
--
作者：
Joya X;Manzano C;Álvarez AT;Mercadal M;Torres F;Salat-Batlle J;Garcia-Algar O
通讯作者：
Garcia-Algar O
影响因子：
3
作者：
Arnett, Anne B.;Pennington, Bruce F.;Olson, Richard K.
通讯作者：
Olson, Richard K.
影响因子：
5.5
作者：
Castles, A;Adams, EK;Boulton, ML
通讯作者：
Boulton, ML
影响因子：
--
作者：
Elkins, Irene J.;McGue, Matt;Iacono, William G.
通讯作者：
Iacono, William G.
影响因子：
4.7
作者：
Benjamin-Garner, Ruby;Stotts, Angela
通讯作者：
Stotts, Angela