Navigating Black Aging: The Biological Consequences of Stress and Depression.
Navigating Black Aging: The Biological Consequences of Stress and Depression.
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DOI：
10.1093/geronb/gbab224
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发表时间：
2022-11-23
影响因子：
6.2
通讯作者：
Thorpe, Roland J., Jr.
中科院分区：
文献类型：
--
作者：
Forrester, Sarah N.;Whitfield, Keith E.;Kiefe, Catarina, I;Thorpe, Roland J., Jr.
在美国，黑人更容易遭受社会不平等。社会不平等和种族歧视造成的长期压力导致身体老化，导致生理失调和生物年龄高于实际年龄（加速老化）。抑郁症与种族歧视和加速老化有关，平均而言，加速老化在黑人中比在白色人中更高。然而，我们对美国黑人生命过程中的加速衰老知之甚少。我们使用混合效应生长模型来测量生物学年龄加速，用心脏代谢标志物测量，在20年的时间里，在分析基线时年龄为27-42岁的年轻人冠状动脉风险发展研究的黑人参与者中。我们纳入了抑郁症状和时间之间的相互作用，以确定抑郁症的风险是否与生物衰老的速度加快有关。我们发现，在20年的时间里，生物衰老的速度在增加，那些有抑郁风险的人比那些没有风险的人的生物衰老速度更快。我们还发现，随着时间的推移，各种社会因素与生物年龄加速有关。鉴于已知的种族歧视和抑郁症状之间的关联，我们提供了一个新的例子，社会不平等的长期影响。具体来说，生物年龄加速，生理失调的标志，与黑人之间的时间和更强烈的抑郁症状之间的相关性。
Black persons in the United States are more likely to suffer from social inequality. Chronic stress caused by social inequality and racial discrimination results in weathering of the body that causes physiological dysregulation and biological age being higher than chronological age (accelerated aging). Depression has been linked to both racial discrimination and accelerated aging and accelerated aging has been demonstrated to be higher in Black than White persons, on average. However, we know little about accelerated aging across the life course in Black Americans. We used mixed-effects growth models to measure biological age acceleration, measured with cardiometabolic markers, over a 20-year period in Black participants of the Coronary Artery Risk Development in Young Adults Study who were aged 27–42 years at analytic baseline. We included an interaction between depressive symptoms and time to determine whether risk of depression was associated with a faster rate of biological aging. We found that the rate of biological aging increased over a 20-year span and that those at risk for depression had a faster rate of biological aging than those not at risk. We also found that various social factors were associated with biological age acceleration over time. Given the known association between perceived racial discrimination and depressive symptoms, we provide a novel instance of the long-term effects of social inequality. Specifically, biological age acceleration, a marker of physiological dysregulation, is associated with time among Black persons and more strongly associated among those with depressive symptoms.
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影响因子：
4.7
作者：
Howick, Jeremy;Kelly, Paul;Kelly, Mike
通讯作者：
Kelly, Mike
DOI：
10.1176/appi.ajp.2018.17060595
发表时间：
2018-08-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Han LKM;Aghajani M;Clark SL;Chan RF;Hattab MW;Shabalin AA;Zhao M;Kumar G;Xie LY;Jansen R;Milaneschi Y;Dean B;Aberg KA;van den Oord EJCG;Penninx BWJH
通讯作者：
Penninx BWJH
影响因子：
4.7
作者：
Forrester, Sarah;Jacobs, David;Kiefe, Catarina, I
通讯作者：
Kiefe, Catarina, I
影响因子：
5.4
作者：
Beck, Audrey N.;Finch, Brian K.;Lin, Shih-Fan;Hummer, Robert A.;Masters, Ryan K.
通讯作者：
Masters, Ryan K.
影响因子：
3.9
作者：
Barber, Sharrelle;Hickson, DeMarc A.;Earls, Felton
通讯作者：
Earls, Felton