What can mice tell us about how vision works?

What can mice tell us about how vision works?
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DOI:
10.1016/j.tins.2011.07.002
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发表时间:
2011-09
影响因子:
15.9
通讯作者:
Niell, Cristopher M.
Niell, Cristopher M.
中科院分区:
医学1区
文献类型:
--
作者:
Huberman, Andrew D.;Niell, Cristopher M.

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了解视觉感知的神经基础是神经科学的一个长期的基本目标。历史上,大多数视觉研究都是在人类、猕猴和猫身上进行的。然而,在过去的五年里,越来越多的研究人员开始使用小鼠来解析视觉处理的潜在机制--其基本原理是,尽管小鼠的敏锐度相对较低,但就可用于标记、监控和操纵特定细胞类型和电路的工具的多样性和复杂性而言,小鼠是无与伦比的。在这篇综述中,我们讨论了在解剖学、接受场和知觉水平上理解小鼠视觉系统的最新进展,重点讨论了这些特征为理解视觉如何工作的目标提供的机会和限制。
Understanding the neural basis of visual perception is a longstanding fundamental goal of neuroscience. Historically, most vision studies were carried out on humans, macaque monkeys and cats. Over the last five years, however, a growing number of researchers have begun using mice to parse the mechanisms underlying visual processing- the rationale is that despite having relatively poor acuity, mice are unmatched in terms of the variety and sophistication of tools available to label, monitor and manipulate specific cell types and circuits. In this review, we discuss recent advances in understanding the mouse visual system at the anatomical, receptive field and perceptual level, focusing on the opportunities and constraints those features provide toward the goal of understanding how vision works.
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