Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person years.
Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person years.
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DOI：
10.1136/bmj.f4539
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发表时间：
2013-08-13
期刊：
影响因子：
--
通讯作者：
Norman JE
中科院分区：
文献类型：
--
作者：
Reynolds RM;Allan KM;Raja EA;Bhattacharya S;McNeill G;Hannaford PC;Sarwar N;Lee AJ;Bhattacharya S;Norman JE
目的确定母亲孕期肥胖是否与成年后代心血管事件死亡率增加相关。设计记录连锁队列分析。从阿伯丁产妇和新生儿数据库中设置出生记录，该数据库与苏格兰死亡总登记处和苏格兰死亡记录系统相关联。人口37709人，从1950年至今有出生记录。主要结局指标：截至2012年1月1日，34-61岁子女的死亡和因心血管事件住院。母亲的体重指数（BMI）是根据第一次产前检查时测量的身高和体重计算的。采用考克斯比例风险回归的事件发生时间分析来检验母亲肥胖对后代结局的影响，以比较BMI为体重不足、超重或肥胖类别的母亲的后代与BMI正常的母亲的后代的结局。 结果在校正了母亲分娩时的年龄、社会经济状况、子女性别、当前年龄、出生体重、分娩时的妊娠和测量BMI时的妊娠后，肥胖母亲（BMI >30）的子女的全因死亡率高于BMI正常的母亲（风险比1.35，95%置信区间1.17 ~ 1.55）。在调整后的模型中，肥胖母亲的后代与BMI正常母亲的后代相比，因心血管事件住院的风险也增加（1.29，1.06至1.57）。超重母亲的后代也有更高的不良后果风险。 结论：母亲肥胖与成年后代过早死亡的风险增加有关。由于英国五分之一的妇女在产前预约时肥胖，迫切需要在怀孕前优化体重的策略。
Objectives To determine whether maternal obesity during pregnancy is associated with increased mortality from cardiovascular events in adult offspring. Design Record linkage cohort analysis. Setting Birth records from the Aberdeen Maternity and Neonatal databank linked to the General Register of Deaths, Scotland, and the Scottish Morbidity Record systems. Population 37 709 people with birth records from 1950 to present day. Main outcome measures Death and hospital admissions for cardiovascular events up to 1 January 2012 in offspring aged 34-61. Maternal body mass index (BMI) was calculated from height and weight measured at the first antenatal visit. The effect of maternal obesity on outcomes in offspring was tested with time to event analysis with Cox proportional hazard regression to compare outcomes in offspring of mothers in underweight, overweight, or obese categories of BMI compared with offspring of women with normal BMI. Results All cause mortality was increased in offspring of obese mothers (BMI >30) compared with mothers with normal BMI after adjustment for maternal age at delivery, socioeconomic status, sex of offspring, current age, birth weight, gestation at delivery, and gestation at measurement of BMI (hazard ratio 1.35, 95% confidence interval 1.17 to 1.55). In adjusted models, offspring of obese mothers also had an increased risk of hospital admission for a cardiovascular event (1.29, 1.06 to 1.57) compared with offspring of mothers with normal BMI. The offspring of overweight mothers also had a higher risk of adverse outcomes. Conclusions Maternal obesity is associated with an increased risk of premature death in adult offspring. As one in five women in the United Kingdom is obese at antenatal booking, strategies to optimise weight before pregnancy are urgently required.
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影响因子：
7.1
作者：
LASKARZEWSKI, P;MORRISON, JA;GLUECK, CJ
通讯作者：
GLUECK, CJ
影响因子：
5.8
作者：
Reynolds, RM;Walker, BR;Phillips, DIW
通讯作者：
Phillips, DIW
DOI：
10.1097/00005768-200207000-00014
发表时间：
2002-07-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Simonen, RL;Pérusse, L;Bouchard, C
通讯作者：
Bouchard, C
DOI：
10.1016/j.ejogrb.2009.01.015
发表时间：
2009-05-01
影响因子：
2.6
作者：
Fattah, Chro;Farah, Nadine;Turner, Michael J.
通讯作者：
Turner, Michael J.
影响因子：
--
作者：
Forsen, T;Eriksson, JG;Barker, DJP
通讯作者：
Barker, DJP