Engineering poly(ionic liquid) semi-IPN hydrogels with fast antibacterial and anti-inflammatory properties for wound healing
Engineering poly(ionic liquid) semi-IPN hydrogels with fast antibacterial and anti-inflammatory properties for wound healing
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工程聚（离子液体）半互穿网络水凝胶具有快速抗菌和抗炎特性，可促进伤口愈合
DOI：
10.1016/j.cej.2020.127429
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发表时间：
2020-10
影响因子：
15.1
通讯作者：
Liu Bo
中科院分区：
文献类型：
--
作者：
Zhou Chao;Sheng Chengju;Gao Lingling;Guo Jia;Li Peng;Liu Bo
由于细菌感染和炎症反应的复杂性，创面愈合治疗的发展不能满足临床需要。为了缩短创面愈合时间，需要开发具有快速抗菌、抗炎、促进细胞迁移和增殖的创面敷料。本文首先合成了两种聚离子液体：聚（1-乙基-3-乙烯基咪唑呋喃-2-羧酸盐）（PEIF）和聚（1-丁基-3-乙烯基咪唑呋喃-2-羧酸盐）（PBIF）。然后将PIL与5wt%蒙脱土（MMT）粘土和2-糠胺改性的透明质酸（HAF）混合，并与四臂马来酰亚胺-聚乙二醇（Mal 4PEG）化学交联形成可降解半互穿网络体外试验表明，合成的半互穿网络（semi-IPN）水凝胶，IPN水凝胶对大肠杆菌和金黄色葡萄球菌表现出较高的抗菌活性。此外，半互穿网络水凝胶可以快速降解，并且PIL从降解的水凝胶中释放时表现出高的抗炎活性。水凝胶降解液中含有糖胺聚糖，有利于细胞增殖和迁移。体内抗感染实验结果进一步证明了半互穿网络水凝胶的抗感染能力。加速感染伤口的愈合。
The development of treatment of wound healing cannot meet clinical requirements owing to the complex bacteria-infection and inflammatory reaction. It is necessary to develop wound dressings that are fast antibacterial property, anti-inflammation and promoting cell migration and proliferation for shortening wound healing period. In this work, we first synthesized two poly(ionic liquids) (PILs): poly(1-ethyl-3-vinylimidazolium furan-2-carboxylate) (PEIF) and poly(1-butyl-3-vinylimidazolium furan-2-carboxylate) (PBIF). The PILs were then mixed with 5 wt% montmorillonite (MMT) clay and 2-furfurylamine-modified hyaluronic acid (HAF), and chemically crosslinked with four-arm maleimide-polyethylene glycol (Mal4PEG) to form degradable semi-inter penetrate network (semi-IPN) hydrogels.In vitroassays demonstrated that the synthesized semi-IPN hydrogels exhibited high antibacterial activities againstEscherichia coliandStaphylococcus aureusdue to the high antibacterial activity of PILs. Furthermore, the semi-IPN hydrogel could be quickly degraded, and the PILs exhibited high anti-inflammatory activities when they were released from degraded hydrogels. The degradation solutions of hydrogels contained glycosaminoglycan, which was beneficial to cell proliferation and migration. Thein vivoanti-infection results further demonstrated that the semi-IPN hydrogels could killS. aureusand accelerate the healing of infected wounds.
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影响因子：
3.1
作者：
Yifang Yang;M. Breadmore;W. Thormann
通讯作者：
Yifang Yang;M. Breadmore;W. Thormann
仿生多功能混合水凝胶促进伤口愈合
影响因子：
19
作者：
Chen, Guopu;Yu, Yunru;Zhao, Yuanjin
通讯作者：
Zhao, Yuanjin
影响因子：
11.2
作者：
E. Montanari;N. Zoratto;L. Mosca;L. Cervoni;E. Lallana;R. Angelini;R. Matassa;T. Coviello;C. Di Meo;P. Matricardi
通讯作者：
E. Montanari;N. Zoratto;L. Mosca;L. Cervoni;E. Lallana;R. Angelini;R. Matassa;T. Coviello;C. Di Meo;P. Matricardi
DOI：
10.1111/j.1749-6632.2001.tb03823.x
发表时间：
2001-11
影响因子：
5.2
作者：
A. Hoffman
通讯作者：
A. Hoffman
影响因子：
9.5
作者：
Ninan, Neethu;Forget, Aurelien;Blencowe, Anton
通讯作者：
Blencowe, Anton