Six-month atrophy in MTL structures is associated with subsequent memory decline in elderly controls.
Six-month atrophy in MTL structures is associated with subsequent memory decline in elderly controls.
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DOI：
10.1016/j.neuroimage.2010.07.016
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发表时间：
2010-12
期刊：
影响因子：
5.7
通讯作者：
Brewer, J. B.
中科院分区：
文献类型：
--
作者：
Murphy, E. A.;Holland, D.;Donohue, M.;McEvoy, L. K.;Hagler, D. J., Jr.;Dale, A. M.;Brewer, J. B.
神经退行性变先于痴呆症（如阿尔茨海默氏症）的发作数年。体积成像的最新进展允许在短至六个月的时间内量化细微的神经解剖学变化。本研究旨在探讨颞叶内侧亚区的神经解剖学改变是否与老年对照组的后期记忆衰退有关。使用基线和6个月随访时获得的高分辨率T1加权磁共振图像，测量来自ADNI队列的142名健康老年受试者（年龄59 - 90岁）的皮质厚度和皮质下体积的变化。回归分析被用来确定是否在14个次区域的变化，选择了先验，与记忆测试从基线到两年的随访性能下降。右侧梭状皮质和下颞叶皮质的厚度变化百分比以及右侧下侧脑室的扩张被认为是随后记忆特异性神经心理学指标下降的重要预测因素。这些结果表明，在健康老年人中，6个月的区域神经退行性变可以量化，并可能有助于识别那些有随后认知能力下降风险的人。
Neurodegeneration precedes the onset of dementias such as Alzheimer’s by several years. Recent advances in volumetric imaging allow quantification of subtle neuroanatomical change over time periods as short as six months. This study investigates whether neuroanatomical change in medial temporal lobe subregions is associated with later memory decline in elderly controls. Using high-resolution, T1-weighted magnetic resonance images acquired at baseline and six months follow-up, change in cortical thickness and subcortical volumes was measured in 142 healthy elderly subjects (aged 59 – 90 years) from the ADNI cohort. Regression analysis was used to identify whether change in fourteen subregions, selected a priori, was associated with declining performance on memory tests from baseline to two years follow-up. Percent thickness change in the right fusiform and inferior temporal cortices and expansion of the right inferior lateral ventricle were found to be significant predictors of subsequent decline on memory-specific neuropsychological measures. These results demonstrate that six-month regional neurodegeneration can be quantified in the healthy elderly and might help identify those at risk for subsequent cognitive decline.
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影响因子：
2.8
作者：
Brewer JB
通讯作者：
Brewer JB
DOI：
10.1523/jneurosci.3252-09.2009
发表时间：
2009-12-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM
通讯作者：
Dale AM
影响因子：
9.9
作者：
Jack, CR;Petersen, RC;Kokmen, E
通讯作者：
Kokmen, E
影响因子：
5.7
作者：
Baron, JC;Chételat, G;Eustache, F
通讯作者：
Eustache, F
影响因子：
--
作者：
Scahill, RI;Frost, C;Fox, NC
通讯作者：
Fox, NC