Measuring lung water: ex vivo validation of multi-image gradient echo MRI.
Measuring lung water: ex vivo validation of multi-image gradient echo MRI.
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DOI：
10.1002/jmri.22600
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发表时间：
2011-07
影响因子：
4.4
通讯作者：
Hopkins, Susan R.
中科院分区：
文献类型：
--
作者：
Holverda, Sebastiaan;Theilmann, Rebecca J.;Sa, Rui C.;Arai, Tatsuya J.;Hall, Evan T.;Dubowitz, David J.;Prisk, G. Kim;Hopkins, Susan R.
旨在确认用于肺水快速（8秒）定量成像的快速梯度回波序列。在矢状面中，在2个充气压力水平（5和15 cm H2O）下，用快速GRE序列对11个切除的猪肺进行三次成像，这是一种改变T2* 但不改变总肺水的干预。在两个紧密间隔的回波之间交替采集图像，并将数据拟合（逐体素）为单个指数以确定T2* 和含水量，并与总水的重量测量值进行比较。5 cm H2O时T2* 平均为1.08±0.02 msec，15 cm H2O时为1.02±0.02 msec（P<0.05）。该测量是可靠的（R2=0.99），平均误差为1.8%。两种含水量测量值之间存在显著的线性关系：在5和15 cm H_2O充气压力下，其关系的回归方程分别为y = 0.92x+19（R2 = 0.94）和y = 1.04x+4（R2=0.96）。Y轴截距与0无统计学差异（P=0.86）。多回波GRE序列是评估肺含水量的可靠和有效的技术。该技术能够快速评估肺水，这对于体内研究是有利的。
To validate a fast gradient echo sequence for rapid (8 sec) quantitative imaging of lung water. Eleven excised pig lungs were imaged with a fast GRE sequence in triplicate, in the sagittal plane at 2 levels of inflation pressure (5 and 15 cm H2O), an intervention that alters T2*, but not total lung water. Images were acquired alternating between two closely spaced echoes and data were fit (voxel-by-voxel) to a single exponential to determine T2* and water content, and compared with gravimetric measurements of total water. T2* averaged 1.08±0.02 msec at 5 cm H2O and 1.02±0.02 msec at 15 cm H2O (P<0.05). The measure was reliable (R2=0.99), with an average mean error of 1.8%. There was a significant linear relationship between the two measures of water content: The regression equations for the relationship were y = 0.92x+19 (R2=0.94), and y = 1.04x+4 (R2=0.96), for 5 and 15 cm H2O inflation pressure respectively. Y-intercepts were not statistically different from 0 (P=0.86). The multi-echo GRE sequence is a reliable and valid technique to assess water content in the lung. This technique enables rapid assessment of lung water, which is advantageous for in vivo studies.
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影响因子：
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作者：
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