Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23.
Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23.
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DOI：
10.1016/j.cmet.2021.04.015
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发表时间：
2021-07-06
期刊：
影响因子：
29
通讯作者：
Lira SA
中科院分区：
文献类型：
--
作者：
He Z;Chen L;Catalan-Dibene J;Bongers G;Faith JJ;Suebsuwong C;DeVita RJ;Shen Z;Fox JG;Lafaille JJ;Furtado GC;Lira SA
遗传易感性和环境因素似乎在炎症性肠病（IBD）的发展中起作用。人类遗传学研究已经将白细胞介素（IL）-23信号通路与IBD联系起来，但导致疾病的环境因素仍然难以捉摸。在这里，我们表明，偶氮染料红40和黄6，世界上最丰富的食用色素，可以触发IBD样结肠炎的小鼠条件性表达IL-23，或在另外两个动物模型中，其中IL-23的表达增加。IL-23表达的增加导致产生表达干扰素-γ的活化的CD 4 + T细胞，并将疾病转移到暴露于Red 40的小鼠中。结肠炎诱导依赖于肠道微生物群促进Red 40的偶氮还原和代谢物1-氨基-2-萘酚-6-磺酸钠盐的产生。总之，这些发现表明，特定的食品着色剂代表了IL-23信号增加的小鼠结肠炎发展的新风险因素。He等人发现，食用着色剂红色40和黄色6在IL-23表达失调的小鼠中诱导结肠炎。结肠炎的发生需要食品着色剂的细菌加工，并且依赖于IL-23诱导的产生IFN-γ的致病性CD 4 + T细胞。
Both genetic predisposition and environmental factors appear to play a role in inflammatory bowel diseases (IBD) development. Genetic studies in humans have linked the interleukin (IL)-23 signaling pathway with IBD, but the environmental factors contributing to disease have remained elusive. Here we show that the azo dyes Red 40 and Yellow 6, the most abundant food colorants in the world, can trigger an IBD-like colitis in mice conditionally expressing IL-23, or in two additional animal models in which IL-23 expression was augmented. Increased IL-23 expression led to generation of activated CD4+ T cells that expressed interferon-γ and transferred disease to mice exposed to Red 40. Colitis induction was dependent on the commensal microbiota promoting the azo reduction of Red 40 and generation of a metabolite, 1-amino-2-naphthol-6-sulphonate sodium salt. Together these findings suggest that specific food colorants represent novel risk factors for development of colitis in mice with increased IL-23 signaling. He et al. find that food colorants Red 40 and Yellow 6 induce colitis in mice with dysregulated expression of IL-23. Colitis development requires bacterial processing of the food colorants and is dependent on IL-23-induced pathogenic CD4+ T cells that produce IFN-γ.
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影响因子：
8
作者：
通讯作者：
--
影响因子：
64.8
作者：
Chassaing B;Koren O;Goodrich JK;Poole AC;Srinivasan S;Ley RE;Gewirtz AT
通讯作者：
Gewirtz AT
影响因子：
4.3
作者：
Honma, Masamitsu
通讯作者：
Honma, Masamitsu
影响因子：
3.7
作者：
Chassaing B;Srinivasan G;Delgado MA;Young AN;Gewirtz AT;Vijay-Kumar M
通讯作者：
Vijay-Kumar M
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K