Neural control of choroidal blood flow.
Neural control of choroidal blood flow.
复制标题
DOI：
10.1016/j.preteyeres.2017.12.001
复制
发表时间：
2018-05
影响因子：
17.8
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Reiner A;Fitzgerald MEC;Del Mar N;Li C
脉络膜由副交感神经、交感神经和三叉神经感觉神经纤维丰富地支配，所述感觉神经纤维调节鸟类和哺乳动物中的脉络膜血流，并且推测也调节其他脊椎动物类别中的脉络膜血流。副交感神经支配已显示血管舒张并增加脉络膜血流量，交感神经输入已显示血管收缩并减少脉络膜血流量，并且感觉输入已显示既集中地传递疼痛和热信息又局部地作用以血管舒张并增加脉络膜血流量。由于脉络膜位于视网膜后面并且不能容易地响应视网膜代谢信号，因此其神经支配对于视网膜活动、驱动脉络膜灌注的全身血压波动以及可能的视网膜温度所需的流量调节是重要的。前两个似乎是由交感神经和副交感神经系统介导的，通过中央电路响应视网膜活动和全身血压，但眼灌注压的调整似乎也受到局部自动调节肌原性机制的影响。脉络膜对温度的适应性反应可能由三叉神经感觉纤维介导。脉络膜血流的神经控制中的损伤随着衰老和各种眼部或全身性疾病如青光眼、年龄相关性黄斑变性（AMD）、高血压和糖尿病而发生，并且可能在这些病症中促成视网膜病理和功能障碍，或者在AMD的情况下是先决条件。本手稿回顾了鸟类和哺乳动物的研究结果，有助于上述总结的脉络膜的自主神经和感觉神经支配的作用，控制脉络膜血流，并在维持视网膜健康的重要性，这种调节。
The choroid is richly innervated by parasympathetic, sympathetic and trigeminal sensory nerve fibers that regulate choroidal blood flow in birds and mammals, and presumably other vertebrate classes as well. The parasympathetic innervation has been shown to vasodilate and increase choroidal blood flow, the sympathetic input has been shown to vasoconstrict and decrease choroidal blood flow, and the sensory input has been shown to both convey pain and thermal information centrally and act locally to vasodilate and increase choroidal blood flow. As the choroid lies behind the retina and cannot respond readily to retinal metabolic signals, its innervation is important for adjustments in flow required by either retinal activity, by fluctuations in the systemic blood pressure driving choroidal perfusion, and possibly by retinal temperature. The former two appear to be mediated by the sympathetic and parasympathetic nervous systems, via central circuits responsive to retinal activity and systemic blood pressure, but adjustments for ocular perfusion pressure also appear to be influenced by local autoregulatory myogenic mechanisms. Adaptive choroidal responses to temperature may be mediated by trigeminal sensory fibers. Impairments in the neural control of choroidal blood flow occur with aging, and various ocular or systemic diseases such as glaucoma, age-related macular degeneration (AMD), hypertension, and diabetes, and may contribute to retinal pathology and dysfunction in these conditions, or in the case of AMD be a precondition. The present manuscript reviews findings in birds and mammals that contribute to the above-summarized understanding of the roles of the autonomic and sensory innervation of the choroid in controlling choroidal blood flow, and in the importance of such regulation for maintaining retinal health.
登录
查看更多内容
影响因子：
3.4
作者：
Bhutto, Imran A.;Baba, Takayuki;Merges, Carol;McLeod, D. Scott;Lutty, Gerard A.
通讯作者：
Lutty, Gerard A.
DOI：
10.1111/j.1748-1716.1976.tb10176.x
发表时间：
1976-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
BILL, A;LINDER, J
通讯作者：
LINDER, J
DOI：
10.1111/j.1748-1716.1973.tb05436.x
发表时间：
1973-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
ALM, A;BILL, A
通讯作者：
BILL, A
DOI：
10.1111/j.1748-1716.1970.tb04765.x
发表时间：
1970-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
ALM, A;BILL, A
通讯作者：
BILL, A
影响因子：
4
作者：
Agassandian, K;Fazan, VPS;Talman, WT
通讯作者：
Talman, WT