Optimization of un-tethered, low voltage, 20-100kHz flexural transducers for biomedical ultrasonics applications.
Optimization of un-tethered, low voltage, 20-100kHz flexural transducers for biomedical ultrasonics applications.
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DOI：
10.1016/j.ultras.2012.03.004
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发表时间：
2012-09
期刊：
影响因子：
4.2
通讯作者：
Lewin, Peter A.
中科院分区：
文献类型：
--
作者：
Sunny, Youhan;Bawiec, Christopher R.;Nguyen, An T.;Samuels, Joshua A.;Weingarten, Michael S.;Zubkov, Leonid A.;Lewin, Peter A.
关键词：
本文介绍了用于生物医学超声波应用的无系留、低电压、20-100 kHz 弯曲传感器的优化。这项工作的目标是设计一种完全可穿戴、重量轻（<100 g）、电池供电的压电超声探头，以最小的激励电压提供最大的输出压力幅度。鉴于越来越多的证据表明，以低于 100 kHz 的频率传递约 100 mW/cm2 的空间峰值时间峰值超声强度 (ISPTP) 可以产生有益的治疗效果，因此需要这种能够在仅 10-25 V 量级的激励电压下运行的超声施用器。有益的治疗应用包括慢性溃疡的伤口处理以及胰岛素和脂质体封装药物的非侵入性透皮递送。 20 kHz 和 100 kHz 涂抹器的早期原型使用最大电功率传输定理进行了优化，该定理需要对安装在适当形状的金属外壳中的压电盘的复阻抗进行细致的分析。在测试的实施中，优化的超声换能器涂抹器由便携式定制电子设备驱动，该电子设备控制激励电压幅度并促进在连续波 (CW) 或具有可调 (10-90%) 占空比的脉冲模式下运行。驱动器单元由远程可充电锂 (Li) 聚合物电池供电。这样做是为了进一步减轻涂抹器单元的重量，使其可佩戴。在约 15 V 的直流电压下，原型能够提供约 55 kPa 或 100 mW/cm2 (ISPTP) 的压力幅度。选择这种水平的声输出是因为它被认为是安全且无副作用的，即使是在长时间暴露的情况下也是如此。
This paper describes optimization of un-tethered, low voltage, 20–100 kHz flexural transducers for biomedical ultrasonics applications. The goal of this work was to design a fully wearable, low weight (<100 g), battery operated, piezoelectric ultrasound applicator providing maximum output pressure amplitude at the minimum excitation voltage. Such implementation of ultrasound applicators that can operate at the excitation voltages on the order of only 10–25 V is needed in view of the emerging evidence that spatial-peak temporal-peak ultrasound intensity (ISPTP) on the order of 100 mW/cm2 delivered at frequencies below 100 kHz can have beneficial therapeutic effects. The beneficial therapeutic applications include wound management of chronic ulcers and non-invasive transdermal delivery of insulin and liposome encapsulated drugs. The early prototypes of the 20 and 100 kHz applicators were optimized using the maximum electrical power transfer theorem, which required a punctilious analysis of the complex impedance of the piezoelectric disks mounted in appropriately shaped metal housings. In the implementation tested, the optimized ultrasound transducer applicators were driven by portable, customized electronics, which controlled the excitation voltage amplitude and facilitated operation in continuous wave (CW) or pulsed mode with adjustable (10–90%) duty cycle. The driver unit was powered by remotely located rechargeable lithium (Li) polymer batteries. This was done to further minimize the weight of the applicator unit making it wearable. With DC voltage of approximately 15 V the prototypes were capable of delivering pressure amplitudes of about 55 kPa or 100 mW/cm2 (ISPTP). This level of acoustic output was chosen as it is considered safe and side effects free, even at prolonged exposure.
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DOI：
10.1088/0022-3735/14/12/017
发表时间：
1981-01-01
期刊：
JOURNAL OF PHYSICS E-SCIENTIFIC INSTRUMENTS
影响因子：
--
作者：
LEWIN, PA;CHIVERS, RC
通讯作者：
CHIVERS, RC
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10.1109/58.726463
发表时间：
1998-09-01
影响因子：
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