Acetaminophen elevates unbound bilirubin levels by the glucose oxidase‐peroxidase method
Acetaminophen elevates unbound bilirubin levels by the glucose oxidase‐peroxidase method
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对乙酰氨基酚通过葡萄糖氧化酶-过氧化物酶法提高未结合胆红素水平
DOI：
10.1111/ped.14608
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发表时间：
2021
影响因子：
1.4
通讯作者：
Yamada Yasumasa
中科院分区：
文献类型：
--
作者：
Ichimura Shintaro;Kakita Hiroki;Asai Shimpei;Mori Mari;Takeshita Satoru;Ueda Hiroko;Kondo Tomoko;Ohashi Wataru;Okumura Akihisa;Yamada Yasumasa
对乙酰氨基酚被广泛应用于新生儿，但其对未结合胆红素（UB）水平的影响尚不清楚。本研究的目的是阐明对乙酰氨基酚是否与UB水平升高有关。方法回顾性分析2017年1月至2020年4月间新生儿重症监护病房收治的出生体重小于1500 g的新生儿。71名婴儿被纳入研究，其中5名接受了对乙酰氨基酚治疗。记录每个婴儿的最高UB值（UB峰），分析临床资料。还收集了UB峰值前24小时内的人口统计数据和治疗信息。葡萄糖氧化酶-过氧化物酶（GOD - POD）法测定UB。根据在UB峰值后24 h内是否给药（对乙酰氨基酚组和未给药组）对婴儿进行分类。然后比较UB值与各临床变量的关系。结果对乙酰氨基酚组的UB峰值和胃肠道疾病发生率均高于未对乙酰氨基酚组。单因素分析显示，共有7个变量与UB峰值潜在相关（P< 0.10）。多因素分析显示，对乙酰氨基酚和直接胆红素与UB峰值独立相关。结论我们的研究表明，通过GOD - POD方法，给药对乙酰氨基酚与UB水平升高有关。用GOD - POD方法测量的UB值不应用于对乙酰氨基酚治疗的婴儿评估胆红素神经毒性避免。
BackgroundAcetaminophen is widely administered to neonates but its effect on unbound bilirubin (UB) levels remains unclear. The aim of this study was to clarify whether administration of acetaminophen is related to an elevation of UB levels.MethodInfants with a birthweight of ˂1,500 g admitted to our neonatal intensive care unit between January 2017 and April 2020 were retrospectively reviewed. Seventy‐one infants were enrolled, five of whom had received acetaminophen. Clinical data were analyzed when the highest UB value (UB peak) in each infant was recorded. Demographic data and information on treatment within the 24 h before the UB peak were also collected. UB was determined by the glucose oxidase‐peroxidase (GOD‐POD) method. Infants were categorized according to the presence or absence of acetaminophen administration (acetaminophen and no acetaminophen groups) within 24 h of the UB peak. The relationship between UB values and various clinical variables was then compared.ResultsBoth the peak UB value and the ratio of gastrointestinal disease were higher in the acetaminophen group than in the no acetaminophen group. Univariate analysis revealed that a total of seven variables were potentially correlated with UB peak values (P< 0.10). Multivariate analysis showed that acetaminophen and direct bilirubin were independently associated with UB peak values.ConclusionOur study suggests that administration of acetaminophen is related to higher UB levels by the GOD‐POD method. UB values measured by the GOD‐POD method should not be used in infants treated with acetaminophen for evaluation of bilirubin neurotoxicity avoidance.
大鼠长期暴露于亚致死剂量的对乙酰氨基酚的影响。
DOI：
--
发表时间：
1991
期刊：
The Central African journal of medicine
影响因子：
--
作者：
E. Udosen;P. Ebong
通讯作者：
P. Ebong
过氧化物酶氧化胆红素的动力学，应用于胆红素-白蛋白结合的研究。
DOI：
10.1080/00365517909106086
发表时间：
1979
影响因子：
2.1
作者：
R. Brodersen;W. Cashore;R. Wennberg;C. Ahlfors;L. F. Rasmussen;D. Shusterman
通讯作者：
D. Shusterman
测定血清游离胆红素以预测低出生体重婴儿的核黄疸
DOI：
--
发表时间：
1992
期刊：
Acta paediatrica Japonica : Overseas edition
影响因子：
--
作者：
Hajime Nakamura;M. Yonetani;Y. Uetani;Masafumi Funato;Yokei Lee
通讯作者：
Yokei Lee