The oral microflora--friend or foe? Can we decide?
The oral microflora--friend or foe? Can we decide?
复制标题
口腔微生物群——朋友还是敌人？
DOI：
--
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发表时间：
2006
影响因子：
3.3
通讯作者：
R. Percival
中科院分区：
文献类型：
--
作者：
P. Marsh;R. Percival
本文讨论了决定口腔微生物菌群在个体生命中是否对健康起有益或有害作用的因素。口腔的常驻微生物群落是多样的，由于其独特的生物和物理特性，与身体其他地方的微生物群落不同。这种天然微生物区系对于宿主生理的正常发育是必不可少的，并且通过排除外源微生物而有助于宿主防御。口腔微生物区系在不同表面（例如牙齿，粘膜）和特定表面（例如裂缝，牙龈缝隙）上的组成不同，表明栖息地的微妙特性影响单个物种的定植和支配能力。这些口腔微生物群落的组成随着时间的推移保持相对稳定（微生物稳态）。这种稳定性并不表明与宿主的被动关系，而是反映了组分物种之间的动态平衡。然而，这种稳定性可能会受到口腔环境或个人生活方式的显著变化的干扰。饮食、药物、吸烟、唾液流动、假牙佩戴、一般健康等的改变可导致口腔微生物菌群的先前次要组分过度生长，这可使部位易患疾病。同样，免疫反应可能在老年时减弱，这可能导致外源性且通常是致病性微生物的定植。口腔微生物也可以作为机会致病菌，并在身体其他部位引起严重疾病。因此，需要积极的口腔保健管理，以维持微生物在整个生命过程中的动态平衡，以确保我们获得我们的居民口腔细菌的好处，而不是遭受他们的恶作剧。
This paper discusses the factors that determine whether the oral microflora play a beneficial or detrimental role in the health of an individual during their life. The resident microflora of the mouth is diverse, and distinct from that found elsewhere in the body due to its unique biological and physical properties. This natural microflora is essential for the normal development of the physiology of the host, and contributes to the host defences by excluding exogenous micro-organisms. The oral microflora varies in composition on distinct surfaces (e.g. teeth, mucosa), and at sites on a specific surface (e.g. fissures, gingival crevice), demonstrating that subtle properties of a habitat influence the ability of individual species to colonise and dominate. The composition of these oral microbial communities remains relatively stable over time (microbial homeostasis). This stability does not indicate a passive relationship with the host, but reflects a dynamic balance among the component species. However, this stability can be perturbed by significant changes to the oral environment or in a person's life-style that occur during the life of an individual. Alterations in diet, medication, smoking, saliva flow, denture wearing, general health, etc, can lead to overgrowth by previously minor components of the oral microflora, which can predispose a site to disease. Likewise, the immune response can wane in old age, which may result in colonisation by exogenous and often pathogenic micro-organisms. Oral micro-organisms can also act as opportunistic pathogens, and cause serious disease elsewhere in the body. Therefore, active oral health care management is needed in order to maintain microbial homeostasis throughout life to ensure that we reap the benefits of our resident oral bacteria and not suffer from their mischief.
影响因子：
3
作者：
Johnson, DA;Yeh, CK;Dodds, MWJ
通讯作者：
Dodds, MWJ
影响因子：
3
作者：
PEARCE, C;BOWDEN, GH;COLE, MF
通讯作者：
COLE, MF
影响因子：
18.6
作者：
Moore, W E;Moore, L V
通讯作者：
Moore, L V