Artifacts Can Be Deceiving: The Actual Location of Deep Brain Stimulation Electrodes Differs from the Artifact Seen on Magnetic Resonance Images.
Artifacts Can Be Deceiving: The Actual Location of Deep Brain Stimulation Electrodes Differs from the Artifact Seen on Magnetic Resonance Images.
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DOI：
10.1159/000526877
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发表时间：
2023
影响因子：
1.7
通讯作者：
Golestanirad, Laleh
中科院分区：
文献类型：
--
作者：
Nuzov, Noa B. B.;Bhusal, Bhumi;Henry, Kaylee R. R.;Jiang, Fuchang;Vu, Jasmine;Rosenow, Joshua M. M.;Pilitsis, Julie G. G.;Elahi, Behzad;Golestanirad, Laleh
关键词：
脑深部电刺激（DBS）是一种常见的治疗各种神经和精神疾病。最近的研究强调了神经成像在定位电极触点相对于目标脑区的位置以优化DBS程控方面的作用。在不同的成像方法中，术后磁共振成像（MRI）已广泛用于DBS电极定位;然而，电极导线引起的几何失真限制了其准确性。在这项工作中，我们研究了电极导线尖端的实际位置和从MRI伪影估计的尖端位置之间的差异在多大程度上取决于MRI序列参数，如采集平面和相位编码方向，以及电极导线的颅外配置。因此，设计并讨论了提高导联定位准确性的成像技术。我们设计并构建了一个植入DBS系统的拟人体模，其中包含18种临床相关配置。在Siemens 1.5 Tesla Aera扫描仪上，使用针对临床使用优化的T1 MPWS序列和针对研究目的优化的<sub>T1</sub><sub></sub>我们改变了切片采集平面和相位编码方向，并计算了DBS电极导线MRI伪影的尾侧尖端与电极导线实际尖端之间的距离（根据MRI参考标记估计）。成像参数和电极导线配置显著改变了MRI伪影内电极导线深度的差异，其差异高达4.99 mm。发现DBS电极导线的实际尖端始终比根据MR图像伪影估计的尖端更靠近嘴侧。使用临床相关序列时，DBS电极导线头端与MRI伪影头端之间的最小差异（即，矢状面和前后位相位编码方向均<sub>为T1</sub>MP3。在术后MR图像上，植入的DBS电极导线的实际头端位于电极导线伪影头端头侧数毫米处。该距离取决于MRI序列参数和DBS系统的颅外轨迹。可以改变MRI参数以改善该定位。
Deep brain stimulation (DBS) is a common treatment for a variety of neurological and psychiatric disorders. Recent studies have highlighted the role of neuroimaging in localizing the position of electrode contacts relative to target brain areas in order to optimize DBS programming. Among different imaging methods, postoperative magnetic resonance imaging (MRI) has been widely used for DBS electrode localization; however, the geometrical distortion induced by the lead limits its accuracy. In this work, we investigated to what degree the difference between the actual location of the lead's tip and the location of the tip estimated from the MRI artifact varies depending on the MRI sequence parameters such as acquisition plane and phase encoding direction, as well as the lead's extracranial configuration. Accordingly, an imaging technique to increase the accuracy of lead localization was devised and discussed. We designed and constructed an anthropomorphic phantom with an implanted DBS system following 18 clinically relevant configurations. The phantom was scanned at a Siemens 1.5 Tesla Aera scanner using a T<sub>1</sub>MPRAGE sequence optimized for clinical use and a T<sub>1</sub>TSE sequence optimized for research purposes. We varied slice acquisition plane and phase encoding direction and calculated the distance between the caudal tip of the DBS lead MRI artifact and the actual tip of the lead, as estimated from MRI reference markers. Imaging parameters and lead configuration substantially altered the difference in the depth of the lead within its MRI artifact on the scale of several millimeters − with a difference as large as 4.99 mm. The actual tip of the DBS lead was found to be consistently more rostral than the tip estimated from the MR image artifact. The smallest difference between the tip of the DBS lead and the tip of the MRI artifact using the clinically relevant sequence (i.e., T<sub>1</sub>MPRAGE) was found with the sagittal acquisition plane and anterior-posterior phase encoding direction. The actual tip of an implanted DBS lead is located up to several millimeters rostral to the tip of the lead's artifact on postoperative MR images. This distance depends on the MRI sequence parameters and the DBS system's extracranial trajectory. MRI parameters may be altered to improve this localization.
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影响因子：
158.5
作者：
Follett, Kenneth A.;Weaver, Frances M.;Reda, Domenic J.
通讯作者：
Reda, Domenic J.
影响因子：
1.7
作者：
Hunsche, Stefan;Sauner, Dieter;Treuer, Harald
通讯作者：
Treuer, Harald
影响因子：
1.7
作者：
Engelhardt, Julien;Guehl, Dominique;Cuny, Emmanuel
通讯作者：
Cuny, Emmanuel
影响因子：
2.5
作者：
Graf, H;Lauer, UA;Schick, F
通讯作者：
Schick, F
影响因子：
3.3
作者：
Golestanirad, Laleh;Keil, Boris;Angelone, Leonardo M.;Bonmassar, Giorgio;Mareyam, Azma;Wald, Lawrence L.
通讯作者：
Wald, Lawrence L.