Ethnicity Influences Risk of Inflammatory Bowel Disease (IBD)-Associated Colon Cancer: A Cross-sectional Analysis of Dysplasia Prevalence and Risk Factors in Hispanics and Non-Hispanic Whites With IBD.
Ethnicity Influences Risk of Inflammatory Bowel Disease (IBD)-Associated Colon Cancer: A Cross-sectional Analysis of Dysplasia Prevalence and Risk Factors in Hispanics and Non-Hispanic Whites With IBD.
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DOI：
10.1093/crocol/otab016
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Abreu MT
中科院分区：
文献类型：
--
作者：
Damas OM;Raffa G;Estes D;Mills G;Kerman D;Palacio A;Schwartz SJ;Deshpande AR;Abreu MT
炎症性肠病（IBD）是西班牙裔美国人的一种新兴疾病。在这项研究中，我们研究了西班牙裔与非西班牙裔白人（NHWs）中IBD相关结肠发育不良（IBD-dys）的患病率，并比较了已建立的临床和环境风险因素的差异。我们对符合结直肠癌监测标准并在2008年至2018年期间在我们中心接受随访的成年西班牙裔和NHWs IBD患者进行了横断面分析。记录临床变量和IBD表型。检查了生活方式IBD-dys的危险因素，包括吸烟和缺乏体力活动。使用多变量回归分析，我们比较了西班牙裔与NHW的IBD患病率，使用相关的协变量。通过受试者工作特性和曲线下面积分析，寻找最佳拟合模型。共纳入445例IBD患者（148例西班牙裔和297例NHW）。两组IBD表型相似，但西班牙裔患者病程较短，克罗恩病相关并发症发生率较低，类固醇使用率较低。西班牙裔和NHW之间监测结肠镜检查的频率相似。西班牙裔和NHW之间的中位体重指数无差异[26.5（IQR 6.0）vs 25.0（IQR 6.0），P = 0.40]。西班牙裔人比NHW更不可能饮酒，但各组之间的吸烟史相似。148名西班牙裔患者中有3名患有IBD-dys（2.02%），而297名NHW中有29名（9.76%）。调整病程、原发性硬化性胆管炎、结肠癌家族史和吸烟等因素后，西班牙裔IBD患病率低于NHW [OR调整后= 0.207（95%CI 0.046-0.938），P = 0.008]。尽管有相似的危险因素，但接受监测的患有IBD的西班牙裔人的IBD-dys患病率低于他们的NHW同行。未来的研究应该检查可能解释风险差异的饮食和微生物因素。
Inflammatory bowel disease (IBD) is an emerging disease in Hispanics. In this study, we examine the prevalence of IBD-related colon dysplasia (IBD-dys) in Hispanics versus non-Hispanic whites (NHWs) and compare differences in established clinical and environmental risk factors. We performed a cross-sectional analysis on adult Hispanics and NHWs with IBD who met criteria for colorectal cancer surveillance and were followed at our center between 2008 and 2018. Clinical variables and IBD phenotype were recorded. Lifestyle IBD-dys risk factors were examined, including smoking and lack of physical activity. Using multivariable regression, we compared the prevalence of IBD-dys in Hispanics versus NHW, using relevant covariates. Receiver operating characteristic and area under the curve were performed to find the best fitting model. A total of 445 IBD patients were included (148 Hispanics and 297 NHWs). IBD phenotype was similar between groups, except that Hispanics had shorter disease duration, a lower frequency of Crohn’s disease-related complications, and lower reported use of steroids. Frequency of surveillance colonoscopies was similar between Hispanics and NHW. There were no differences in median body mass index between Hispanics and NHW [26.5 (IQR 6.0) vs 25.0 (IQR 6.0), P = 0.40]. Hispanics were less likely than NHW to consume alcohol but smoking history was similar between groups. Three out of 148 Hispanic patients had IBD-dys (2.02%) compared to 29 out of 297 NHWs (9.76%). Adjusting for disease duration, primary sclerosing cholangitis, family history of colon cancer, and smoking, Hispanics had a lower prevalence of IBD-dys compared to NHW [ORadjusted = 0.207 (95% CI 0.046–0.938), P = 0.008]. Hispanics with IBD undergoing surveillance had a lower prevalence of IBD-dys than their NHW counterparts, despite similar risk factors. Future studies should examine dietary and microbial factors that may explain differences in risk.
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DOI：
10.1007/s10552-013-0201-5
发表时间：
2013-06
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Johnson CM;Wei C;Ensor JE;Smolenski DJ;Amos CI;Levin B;Berry DA
通讯作者：
Berry DA
影响因子：
--
作者：
Barzi A;Yang D;Mostofizadeh S;Lenz HJ
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Lenz HJ
影响因子：
168.9
作者：
Olen, Ola;Erichsen, Rune;Ludvigsson, Jonas F.
通讯作者：
Ludvigsson, Jonas F.
影响因子：
2.5
作者：
Reveron, Dayana;Lopez, Christian;Coppola, Domenico
通讯作者：
Coppola, Domenico
影响因子：
8
作者：
Shaha, Shailja C.;Itzkowitz, Steven H.
通讯作者：
Itzkowitz, Steven H.