Meta-analyses of colorectal cancer risk factors.
Meta-analyses of colorectal cancer risk factors.
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DOI：
10.1007/s10552-013-0201-5
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Berry DA
中科院分区：
文献类型：
--
作者：
Johnson CM;Wei C;Ensor JE;Smolenski DJ;Amos CI;Levin B;Berry DA
人口统计学、行为和环境因素与结直肠癌（CRC）风险增加相关。我们回顾了已发表的证据，并探讨了危险因素与CRC发病率之间的关系。我们确定了12个确定的非筛查CRC风险因素，并进行了全面的审查和荟萃分析，以量化每个因素对CRC风险的影响。我们使用随机效应模型的风险在不同的研究：逆方差加权平均值的二分因素和广义最小二乘剂量反应的多水平因素。重要的风险因素包括炎症性肠病（RR = 2.93，95% CI：1.79-4.81）;一级亲属中有CRC病史（RR = 1.79，95% CI：1.60-2.02）;总体人群的体重指数（BMI）（RR = 1.10/8 kg/m2增加，95% CI：1.08-1.12）;体力活动（RR = 0.88，95% CI：0.86-0.91，2个标准差增加体力活动评分）;吸烟（RR = 1.06，95% CI：1.03-1.08，5包-年），以及红肉的摄入量（RR = 1.13，95%CI：1.09-1.16，5份/周），水果（RR = 0.85，95%CI：0.75-0.96，3份/天），和蔬菜（RR = 0.86，95%CI：0.78-0.94，5份/天）。我们开发了一种综合风险建模策略，该策略结合多种效应来预测个体患结直肠癌的风险。一级亲属中的炎症性肠病和CRC病史与CRC的高风险相关。BMI增加、红肉摄入、吸烟、体力活动少、蔬菜摄入量低和水果摄入量低与CRC风险中度增加相关。
Demographic, behavioral and environmental factors have been associated with increased risk of colorectal cancer (CRC). We reviewed the published evidence and explored associations between risk factors and CRC incidence. We identified 12 established non-screening CRC risk factors and performed a comprehensive review and meta-analyses to quantify each factor’s impact on CRC risk. We used random effects models of the logarithms of risks across studies: inverse variance weighted averages for dichotomous factors and generalized least squares for dose-response for multi-level factors. Significant risk factors include inflammatory bowel disease (RR = 2.93, 95% CI: 1.79–4.81); CRC history in first-degree relative (RR = 1.79, 95% CI: 1.60–2.02); body mass index (BMI) to overall population (RR = 1.10 per 8 kg/m2 increase, 95% CI: 1.08–1.12); physical activity (RR = 0.88, 95% CI: 0.86–0.91 for 2 standard deviations increased physical activity score); cigarette smoking (RR = 1.06, 95% CI: 1.03–1.08 for 5 pack-years), and consumption of red meat (RR = 1.13, 95% CI: 1.09–1.16 for 5 servings/week), fruit (RR = 0.85, 95% CI: 0.75–0.96 for 3 servings/day), and vegetables (RR = 0.86, 95% CI: 0.78–0.94 for 5 servings/day). We developed a comprehensive risk modeling strategy that incorporates multiple effects to predict an individual’s risk of developing colorectal cancer. Inflammatory bowel disease and history of CRC in first-degree relatives are associated with much higher risk of CRC. Increased BMI, red meat intake, cigarette smoking, low physical activity, low vegetable consumption, and low fruit consumption were associated with moderately increased risk of CRC.
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影响因子：
29.4
作者：
Askling, J;Dickman, PW;Ekbom, A
通讯作者：
Ekbom, A
影响因子：
12.6
作者：
Boardman, Lisa A.;Morlan, Bruce W.;Gallinger, Steven
通讯作者：
Gallinger, Steven
影响因子：
8.4
作者：
Butterworth, AS;Higgins, JPT;Pharoah, P
通讯作者：
Pharoah, P
影响因子：
8.4
作者：
Akhter, Munira;Kuriyama, Shinichi;Tsuji, Ichiro
通讯作者：
Tsuji, Ichiro
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N