Selectivity of Monaural Synaptic Inputs Underlying Binaural Auditory Information Integration in the Central Nucleus of Inferior Colliculus.
Selectivity of Monaural Synaptic Inputs Underlying Binaural Auditory Information Integration in the Central Nucleus of Inferior Colliculus.
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DOI：
10.3389/fncel.2018.00303
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发表时间：
2018
影响因子：
5.3
通讯作者：
Xiao Z
中科院分区：
文献类型：
--
作者：
Wei J;Zhong W;Xiao C;Liu Y;Song C;Xiao Z
下丘中央核（ICC）的神经元接受来自同侧和对侧听觉通路的上行输入。然而，同侧和对侧刺激诱发的兴奋性或抑制性突触输入对ICC神经元听觉反应的贡献尚不清楚。使用在体全细胞电压钳记录，我们研究了兴奋性和抑制性突触电流的ICC神经元在双耳刺激进行强度-强度扫描。为了系统分析同侧耳和对侧耳的贡献，将声强从0 dB声压级（SPL）到70 dB SPL随机传递到每一侧。虽然在弱声强时，对侧输入对突触反应起主导作用，但在较高声强时，对侧刺激可增加（或减少）突触反应。有趣的是，对侧声输入的突触反应并不与同侧的线性叠加。相比之下，反应显示出对侧或同侧的轮廓，这取决于哪一个更占主导地位。这种变化发生在某个强度“切换”点。因此，ICC神经元的双耳听觉反应不是简单地由同侧和对侧刺激诱发的输入的总和介导的。这表明，ICC可能继承了整合在脑干的声信息，导致单耳兴奋和抑制的选择性，神经元双耳声反应的基础。
Neurons in the central nucleus of the inferior colliculus (ICC) receive ascending inputs from the ipsilateral and contralateral auditory pathway. However, the contributions of excitatory or inhibitory synaptic inputs evoked by ipsilateral and contralateral stimuli to auditory responses of ICC neurons remain unclear. Using in vivo whole-cell voltage-clamp recordings, we investigated excitatory and inhibitory synaptic currents in neurons of the ICC in response to binaural stimulation by performing an intensity-intensity scan. To systematically analyze the contribution of the ipsilateral and contralateral ear, the sound intensity was randomly delivered to each side from 0 dB sound pressure level (SPL) to 70 dB SPL. Although the synaptic responses were dominated by contralateral inputs at weak sound intensities, they could be increased (or decreased) by additional ipsilateral stimulation at higher intensities. Interestingly, the synaptic responses to contralateral acoustic inputs were not linearly superimposed with the ipsilateral ones. By contrast, the responses showed either a contralateral or ipsilateral profile, depending on which one was more dominant. This change occurred at a certain intensity “switch” point. Thus, the binaural auditory responses of the ICC neurons were not simply mediated by the summation of the inputs evoked by ipsilateral and contralateral stimulations. This suggested that the ICC might inherit the acoustic information integrated at the brainstem, causing the selectivity of monaural excitation and inhibition to underlie the neuronal binaural acoustic response.
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