Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction.
Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction.
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DOI：
10.1002/nbm.1610
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发表时间：
2011-06
影响因子：
2.9
通讯作者：
Helpern, Joseph A.
中科院分区：
文献类型：
--
作者：
Jensen, Jens H.;Falangola, Maria F.;Hu, Caixia;Tabesh, Ali;Rapalino, Otto;Lo, Calvin;Helpern, Joseph A.
通过应用扩散峰度成像的MRI方法，在症状发作后13-26小时，在三名中风受试者的脑缺血性病变内观察到扩散峰度显著增加。这种增加被解释为可能反映了与正常出现的对侧组织相比，病变中更高程度的扩散异质性。此外，对于其中两名白色物质梗死的受试者，这种增加具有很强的纤维束方向依赖性。有人提出，这种效果是一致的轴突内扩散率的大幅下降，可能与轴突静脉曲张或与内质网相关的改变。
By application of the MRI method of diffusional kurtosis imaging, a substantially increased diffusional kurtosis was observed within the cerebral ischemic lesions of three stroke subjects, 13–26 h following the onset of symptoms. This increase is interpreted as probably reflecting a higher degree of diffusional heterogeneity in the lesions when compared with normal-appearing contralateral tissue. In addition, for two of the subjects with white matter infarcts, the increase had a strong fiber tract orientational dependence. It is proposed that this effect is consistent with a large drop in the intra-axonal diffusivity, possibly related to either axonal varicosities or alterations associated with the endoplasmic reticulum.
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影响因子：
2.9
作者：
Jensen, Jens H.;Helpern, Joseph A.
通讯作者：
Helpern, Joseph A.
影响因子：
4.7
作者：
Hou, Sheng T.;Jiang, Susan X.;Kaibuchi, Kozo
通讯作者：
Kaibuchi, Kozo
影响因子：
3.3
作者：
Jensen, JH;Helpern, JA;Kaczynski, K
通讯作者：
Kaczynski, K
影响因子：
3.3
作者：
SZAFER, A;ZHONG, JH;GORE, JC
通讯作者：
GORE, JC
影响因子：
3
作者：
Tamura, Hajime;Kurihara, Noriko;Shimosegawa, Eku
通讯作者：
Shimosegawa, Eku