Childhood infection and adult schizophrenia: a meta-analysis of population-based studies.
Childhood infection and adult schizophrenia: a meta-analysis of population-based studies.
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DOI：
10.1016/j.schres.2012.05.023
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发表时间：
2012-08
影响因子：
4.5
通讯作者：
Jones, Peter B.
中科院分区：
文献类型：
--
作者：
Khandaker, Golam M.;Zimbron, Jorge;Dalman, Christina;Lewis, Glyn;Jones, Peter B.
关键词：
确定儿童期暴露于累及中枢神经系统或其他部位的感染性疾病是否与成人精神分裂症或其他精神病相关。通过电子和手动检索确定的已发表文献的系统性综述和荟萃分析，符合三个纳入标准：人群基础、个体水平儿童感染的客观评估、成人精神病结局的标准定义。我们计算了所有CNS感染的风险比，并分别计算了与非情感性精神病和精神分裂症相关的病毒和细菌感染的风险比，并在荟萃分析中合并。纳入了7项研究。涉及2424例病例和超过120万对照的荟萃分析显示，CNS病毒感染与成人非情感性精神病风险增加近两倍相关（风险比1.70; 95%CI 1.13-2.55; p = 0.01）。研究间无显著异质性（p = 0.26; I2 = 20%）。涉及1035例病例和超过120万对照的单独荟萃分析表明，所有儿童CNS感染，特别是病毒感染，可能与成人精神分裂症的近两倍风险相关。然而，有证据表明这些研究之间存在一定的异质性（p = 0.07; I2 = 70%）。中枢神经系统细菌感染与精神病风险无关。没有明显累及中枢神经系统的儿童感染数据不足。这些发现表明儿童中枢神经系统病毒感染增加了成年精神病的风险。可能的机制可能包括病原体的直接影响和炎症反应对发育中的大脑的影响。
To determine whether exposures to infectious illness during childhood involving the CNS or elsewhere is associated with adult schizophrenia or other psychoses. Systematic review and meta-analysis of published literature identified by electronic and manual search meeting three inclusion criteria: population-base, objective assessment of childhood infection at the individual level, standard definition of adult psychotic outcomes. We calculated risk ratio for all CNS infection, and separately for viral and bacterial infection in relation to non-affective psychosis and schizophrenia, which was combined in meta-analysis. Seven studies were included. Meta-analysis involving 2424 cases and over 1.2 million controls showed CNS viral infection was associated with nearly two-fold increased risk of adult non-affective psychosis (risk ratio 1.70; 95% CI 1.13–2.55; p = 0.01). There was no significant heterogeneity between studies (p = 0.26; I2 = 20%). Separate meta-analysis involving 1035 cases and over 1.2 million controls suggested all childhood CNS infections, particularly viral infections, may be associated with nearly two-fold risk of adult schizophrenia. However, there was evidence of some heterogeneity between these studies (p = 0.07; I2 = 70%). CNS bacterial infections were not associated with risk of psychosis. Data on childhood infections with no obvious involvement of the CNS is insufficient. These findings indicate childhood CNS viral infections increase the risk of adult psychotic illness. Possible mechanisms may include both direct effects of pathogens, and the effects of inflammatory response on the developing brain.
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影响因子：
15.1
作者：
Buka, SL;Tsuang, MT;Yolken, RH
通讯作者：
Yolken, RH
影响因子：
4.5
作者：
Khandaker, Golam M.;Barnett, Jennifer H.;White, Ian R.;Jones, Peter B.
通讯作者：
Jones, Peter B.
DOI：
10.1007/s00406-004-0485-2
发表时间：
2004-02-01
影响因子：
4.7
作者：
Koponen, H;Rantakallio, P;Isohanni, M
通讯作者：
Isohanni, M
影响因子：
17.7
作者：
Brown, AS;Hooton, J;Susser, ES
通讯作者：
Susser, ES
影响因子：
4.8
作者：
Bayer, TA;Falkai, P;Maier, W
通讯作者：
Maier, W