Cerebrovascular risk factors and brain microstructural abnormalities on diffusion tensor images in HIV-infected individuals.
Cerebrovascular risk factors and brain microstructural abnormalities on diffusion tensor images in HIV-infected individuals.
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DOI：
10.1007/s13365-012-0106-1
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发表时间：
2012-08
影响因子：
3.2
通讯作者：
Shikuma, Cecilia M.
中科院分区：
文献类型：
--
作者：
Nakamoto, Beau K.;Jahanshad, Neda;McMurtray, Aaron;Kallianpur, Kalpana J.;Chow, Dominic C.;Valcour, Victor G.;Paul, Robert H.;Marotz, Liron;Thompson, Paul M.;Shikuma, Cecilia M.
尽管进行了有效的抗逆转录病毒治疗，但艾滋病毒相关的神经认知障碍在艾滋病毒感染者中仍然普遍存在。随着这些人年龄的增长，共病脑血管疾病可能会影响认知功能。需要有效的工具来研究这种影响。本研究使用扩散张量成像（DTI）来表征有和无脑血管危险因素的HIV感染者的脑微结构变化。弥散加权MRI获得了22例HIV感染者年龄50岁或以上（平均年龄= 58岁，标准差= 6岁; 19名男性，3名女性）。计算张量以获得分数各向异性（FA）和平均扩散率（MD）图。在有和没有脑血管危险因素的组之间进行多重比较的统计学比较。葡萄糖代谢异常（即，空腹血糖受损、葡萄糖耐量受损或糖尿病）与尾状核中显著较高的MD（错误发现率（FDR）临界p值= 0.008）和较低的FA（FDR临界p值= 0.002）以及海马中较低的FA（FDR临界p值= 0.004）相关。在尾状核和海马的DTI测量值与年龄和教育调整的整体认知功能、记忆力和精神速度的综合评分之间进行Pearson相关性分析。神经影像学测量和认知测量之间没有可检测到的相关性。总之，我们证明了大脑的微结构异常与HIV感染者的尾状核和海马的葡萄糖代谢异常有关。深部灰质结构和海马可能是脆弱的受试者共病糖代谢异常，但我们的结果应在进一步的研究中证实。
HIV-associated neurocognitive disorder remains prevalent in HIV-infected individuals despite effective antiretroviral therapy. As these individuals age, comorbid cerebrovascular disease will likely impact cognitive function. Effective tools to study this impact are needed. This study used diffusion tensor imaging (DTI) to characterize brain microstructural changes in HIV-infected individuals with and without cerebrovascular risk factors. Diffusion-weighted MRIs were obtained in 22 HIV-infected subjects aged 50 years or older (mean age = 58 years, standard deviation = 6 years; 19 males, three females). Tensors were calculated to obtain fractional anisotropy (FA) and mean diffusivity (MD) maps. Statistical comparisons accounting for multiple comparisons were made between groups with and without cerebrovascular risk factors. Abnormal glucose metabolism (i.e., impaired fasting glucose, impaired glucose tolerance, or diabetes mellitus) was associated with significantly higher MD (false discovery rate (FDR) critical p value = 0.008) and lower FA FDR critical p value = 0.002) in the caudate and lower FA in the hippocampus (FDR critical p value = 0.004). Pearson correlations were performed between DTI measures in the caudate and hippocampus and age- and education-adjusted composite scores of global cognitive function, memory, and psychomotor speed. There were no detectable correlations between the neuroimaging measures and measures of cognition. In summary, we demonstrate that brain microstructural abnormalities are associated with abnormal glucose metabolism in the caudate and hippocampus of HIV-infected individuals. Deep gray matter structures and the hippocampus may be vulnerable in subjects with comorbid abnormal glucose metabolism, but our results should be confirmed in further studies.
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影响因子：
3.2
作者：
Becker, James T.;Sanders, Joanne;Madsen, Sarah K.;Ragin, Ann;Kingsley, Lawrence;Maruca, Victoria;Cohen, Bruce;Goodkin, Karl;Martin, Eileen;Miller, Eric N.;Sacktor, Ned;Alger, Jeffery R.;Barker, Peter B.;Saharan, Priyanka;Carmichael, Owen T.;Thompson, Paul M.
通讯作者：
Thompson, Paul M.
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
--
作者：
Brown, TT;Cole, SR;Dobs, AS
通讯作者：
Dobs, AS
影响因子：
6.2
作者：
Chang, L.;Yakupov, R.;Ernst, T.
通讯作者：
Ernst, T.
糖尿病的医疗标准 - 2009年。
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association