Oleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer's patches of mice.
Oleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer's patches of mice.
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DOI：
10.1038/s41598-018-32925-x
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发表时间：
2018-10-05
影响因子：
4.6
通讯作者：
Passani MB
中科院分区：
文献类型：
--
作者：
Di Paola M;Bonechi E;Provensi G;Costa A;Clarke G;Ballerini C;De Filippo C;Passani MB
The lipid sensor oleoylethanolamide (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor-α (PPAR-α) secreted in the proximal intestine, is endowed with several distinctive homeostatic properties, such as control of appetite, anti-inflammatory activity, stimulation of lipolysis and fatty acid oxidation. When administered exogenously, OEA has beneficial effects in several cognitive paradigms; therefore, in all respects, OEA can be considered a hormone of the gut-brain axis. Here we report an unexplored modulatory effect of OEA on the intestinal microbiota and on immune response. Our study shows for the first time that sub-chronic OEA administration to mice fed a normal chow pellet diet, changes the faecal microbiota profile, shifting the Firmicutes:Bacteroidetes ratio in favour of Bacteroidetes (in particular Bacteroides genus) and decreasing Firmicutes (Lactobacillus), and reduces intestinal cytokines expression by immune cells isolated from Peyer’s patches. Our results suggest that sub-chronic OEA treatment modulates gut microbiota composition towards a “lean-like phenotype”, and polarises gut-specific immune responses mimicking the effect of a diet low in fat and high in polysaccharides content.
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影响因子：
6.7
作者：
Hines IN;Kremer M;Moore SM;Wheeler MD
通讯作者：
Wheeler MD
影响因子：
3.9
作者：
Calvani R;Picca A;Lo Monaco MR;Landi F;Bernabei R;Marzetti E
通讯作者：
Marzetti E
影响因子：
3.7
作者：
Armougom F;Henry M;Vialettes B;Raccah D;Raoult D
通讯作者：
Raoult D
影响因子：
3.7
作者：
Kim KA;Gu W;Lee IA;Joh EH;Kim DH
通讯作者：
Kim DH
DOI：
10.15252/embj.201797537
发表时间：
2018-03-01
期刊：
The EMBO journal
影响因子：
--
作者：
Sáez de Guinoa J;Jimeno R;Gaya M;Kipling D;Garzón MJ;Dunn-Walters D;Ubeda C;Barral P
通讯作者：
Barral P