Serum antioxidants and inflammation predict red cell distribution width in older women: the Women's Health and Aging Study I.
Serum antioxidants and inflammation predict red cell distribution width in older women: the Women's Health and Aging Study I.
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DOI：
10.1016/j.clnu.2010.03.001
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Fried LP
中科院分区：
文献类型：
--
作者：
Semba RD;Patel KV;Ferrucci L;Sun K;Roy CN;Guralnik JM;Fried LP
红细胞分布宽度（RDW）是循环红细胞大小异质性的衡量标准，与一些慢性疾病相关并可预测死亡率。虽然氧化损伤和炎症已被理论化影响RDW，但抗氧化剂和炎症与RDW的关系尚未得到很好的表征。目的是确定血清总类胡萝卜素、α-生育酚、硒、蛋白质羰基和白细胞介素-6（IL-6）是否与RDW相关，并预测RDW随时间的变化。在马里兰州的巴尔的摩进行的妇女健康与老龄化研究I中，在基线、12个月和24个月随访时测量了786名年龄≥65岁的中度至重度残疾社区居民妇女的RDW。在调整其他协变量的独立多变量混合效应模型中，硒与基线RDW显著相关，并可预测两年随访期间的RDW。正如预期的那样，向模型中添加IL-6减弱了血清硒与RDW的关联，因为已知低抗氧化剂水平会上调IL-6。总类胡萝卜素与RDW在基线和一年随访。蛋白质羰基和α-生育酚与RDW无显著相关性。血清硒是RDW的独立预测因子，并可能通过IL-6介导对RDW的影响。
Red cell distribution width (RDW), a measure of heterogeneity in the size of circulating erythrocytes, is associated with some chronic diseases and predicts mortality. Although oxidative damage and inflammation have been theorized to affect RDW, the relationships of antioxidants and inflammation with RDW have not been well characterized. The aims were to determine whether total serum carotenoids, α-tocopherol, selenium, protein carbonyls, and interleukin-6 (IL-6) are associated with RDW and predict RDW over time. RDW was measured at baseline, 12 months, and 24 months follow-up in 786 moderately to severely disabled community-dwelling women, aged ≥65 years, in the Women’s Health and Aging Study I in Baltimore, Maryland. Selenium was significantly associated with RDW at baseline and predicted RDW over two years’ follow-up in separate multivariate mixed effects models that adjusted for other covariates. As expected, the addition of IL-6 to the models attenuated the association of serum selenium with RDW, as low antioxidant levels are known to upregulate IL-6. Total carotenoids were associated with RDW at baseline and one year follow-up. Protein carbonyls and α-tocopherol were not significantly associated with RDW. Serum selenium is an independent predictor of RDW and may potentially mediate effects on RDW through IL-6.
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影响因子：
6.3
作者：
Hengstermann, Susanne;Valentini, Luzia;Lochs, Herbert
通讯作者：
Lochs, Herbert
影响因子：
20.3
作者：
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影响因子：
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1.9
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作者：
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