Middle-age dementia risk scores and old-age cognition: a quasi-experimental population-based twin study with over 20-year follow-up.
Middle-age dementia risk scores and old-age cognition: a quasi-experimental population-based twin study with over 20-year follow-up.
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DOI：
10.1136/jnnp-2020-324009
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Vuoksimaa E
中科院分区：
文献类型：
--
作者：
Iso-Markku P;Kaprio J;Lindgren N;Rinne JO;Vuoksimaa E
中年风险分数预测认知障碍，但不知道在控制共同的遗传和环境因素时，这些关联是否明显。使用两个风险评分，自我报告的教育职业评分和心血管危险因素，衰老和痴呆（CAIDE），我们调查了具有较高中年痴呆风险的双胞胎与具有较低风险的双胞胎相比，是否具有较差的老年认知。我们使用了一项基于人群的老年芬兰双胞胎队列研究，中年问卷数据（n=15 169，平均年龄=52.0岁，SD=11.8）和老年认知通过电话采访测量（平均年龄=74.1，SD=4.1，n=4302）。进行家庭间和家庭内线性回归分析。在家庭间分析（N=2359）中，较高的教育-职业评分与较好的认知相关（B=0.76，95% CI 0.69至0.83），较高的CAIDE评分与较差的认知相关（B=-0.73，95% CI-0.82至-0.65）。在双卵（DZ）对中，双生子内教育-职业得分的差异与双生子内认知差异显著相关（B=0.78，95% CI 0.25 ~ 1.31; N=338），但在单卵（MZ）对中则不相关（B=0.12，95% CI −0.44 ~ 0.68; N=221）。双胞胎内CAIDE评分的差异与双胞胎内认知差异无关：DZ B=-0.38（95% CI-0.90至0.14，N=343）和MZ B=-0.05（95% CI-0.59至0.49，N=226）。中年痴呆风险评分预测老年认知，但在双对分析中，几乎没有支持独立于共享环境和遗传因素的关联。了解风险评分-认知关联的遗传基础对于早期发现痴呆症和设计干预试验非常重要。
Middle-age risk scores predict cognitive impairment, but it is not known if these associations are evident when controlling for shared genetic and environmental factors. Using two risk scores, self-report educational-occupational score and Cardiovascular Risk Factors, Aging and Dementia (CAIDE), we investigated if twins with higher middle-age dementia risk have poorer old-age cognition compared with their co-twins with lower risk. We used a population-based older Finnish Twin Cohort study with middle-age questionnaire data (n=15 169, mean age=52.0 years, SD=11.8) and old-age cognition measured via telephone interview (mean age=74.1, SD=4.1, n=4302). Between-family and within-family linear regression analyses were performed. In between-family analyses (N=2359), higher educational-occupational score was related to better cognition (B=0.76, 95% CI 0.69 to 0.83) and higher CAIDE score was associated with poorer cognition (B=−0.73, 95% CI −0.82 to -0.65). Within twin-pair differences in educational-occupational score were significantly related to within twin-pair differences in cognition in dizygotic (DZ) pairs (B=0.78, 95% CI 0.25 to 1.31; N=338) but not in monozygotic (MZ) pairs (B=0.12, 95% CI −0.44 to 0.68; N=221). Within twin-pair differences in CAIDE score were not related to within twin-pair differences in cognition: DZ B=−0.38 (95% CI −0.90 to 0.14, N=343) and MZ B=−0.05 (95% CI −0.59 to 0.49; N=226). Middle-age dementia risk scores predicted old-age cognition, but within twin-pair analyses gave little support for associations independent of shared environmental and genetic factors. Understanding genetic underpinnings of risk score−cognition associations is important for early detection of dementia and designing intervention trials.
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DOI：
10.1177/1745691610383511
发表时间：
2010-09
期刊：
Perspectives on psychological science : a journal of the Association for Psychological Science
影响因子：
--
作者：
McGue M;Osler M;Christensen K
通讯作者：
Christensen K
影响因子：
8.2
作者：
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通讯作者：
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DOI：
10.3233/jad-180013
发表时间：
2018
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Kuźma E;Hannon E;Zhou A;Lourida I;Bethel A;Levine DA;Lunnon K;Thompson-Coon J;Hyppönen E;Llewellyn DJ
通讯作者：
Llewellyn DJ
影响因子：
2.4
作者：
Järvenpää, T;Rinne, JO;Kaprio, J
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Kaprio, J
影响因子：
5.7
作者：
Lopez, Oscar L;Kuller, Lewis H
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Kuller, Lewis H