Up-regulation of the expression of leucine-rich alpha(2)-glycoprotein in hepatocytes by the mediators of acute-phase response.
Up-regulation of the expression of leucine-rich alpha(2)-glycoprotein in hepatocytes by the mediators of acute-phase response.
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急性期反应介质在肝细胞中富含亮氨酸α的表达（2） - 糖蛋白的表达。
DOI：
10.1016/j.bbrc.2009.03.104
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发表时间：
2009-05-15
影响因子：
3.1
通讯作者：
Inoue S
中科院分区：
文献类型：
--
作者：
Shirai R;Hirano F;Ohkura N;Ikeda K;Inoue S
富含亮氨酸的α2-糖蛋白（Leucine-rich α2-glycoprotein，LRG）是一种血浆蛋白，其中富含亮氨酸的重复序列（Leucine-rich Repeats，LRRs）最早被发现。虽然LRG的生理功能尚不清楚，但已报道在各种疾病中血清LRG水平升高。在本研究中，我们发现重组人IL-6在人肝癌HepG 2细胞中诱导LRG。IL-6对LRG的诱导与IL-1β或TNFα协同上调，其模式与1型急性期蛋白相似。我们还发现，脂多糖（LPS）给小鼠腹腔注射增强剂量依赖性的LRG mRNA的表达在肝脏以及小鼠的主要急性期蛋白。这些结果有力地表明，LRG是一种分泌型1急性时相蛋白，其表达由急性时相反应介质上调。
Leucine-rich α2-glycoprotein (LRG) is a plasma protein in which leucine-rich repeats (LRRs) were first discovered. Although the physiological function of LRG is not known, increases in the serum level of LRG have been reported in various diseases. In this study, we found that LRG was induced by recombinant human IL-6 in human hepatoma HepG2 cells. The induction of LRG by IL-6 was up-regulated synergistically with either IL-1β or TNFα in a pattern similar to those for type 1 acute-phase proteins. We also found that lipopolysaccharide (LPS) administered intraperitoneally to mice enhanced dose-dependently the expression of LRG mRNA in the liver as well as those for mouse major acute-phase proteins. These results strongly suggest that LRG was a secretory type 1 acute-phase protein whose expression was up-regulated by the mediator of acute-phase response.
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DOI：
10.1515/bchm2.1977.358.1.639
发表时间：
1977-01-01
影响因子：
--
作者：
HAUPT, H;BAUDNER, S
通讯作者：
BAUDNER, S
影响因子：
4.8
作者：
Okumura, K;Ohkura, N;Hayashi, K
通讯作者：
Hayashi, K
脊椎动物Toll样受体中富含亮氨酸重复序列（LRR）的比较序列分析。
影响因子：
4.4
作者：
Matsushima, Norio;Tanaka, Takanori;Enkhbayar, Purevjav;Mikami, Tomoko;Taga, Masae;Yamada, Keiko;Kuroki, Yoshio
通讯作者：
Kuroki, Yoshio
ELISA用于富含细胞色素c的人血清含有富含浅亮氨酸的α-2-糖蛋白-1作为捕获的配体。
影响因子：
2.2
作者：
Weivoda S;Andersen JD;Skogen A;Schlievert PM;Fontana D;Schacker T;Tuite P;Dubinsky JM;Jemmerson R
通讯作者：
Jemmerson R
影响因子：
2.5
作者：
Li, Xianfeng;Miyajima, Masakazu;Arai, Hajime
通讯作者：
Arai, Hajime