Intergenerational accumulation of impairments in maternal behavior following postnatal social stress.
Intergenerational accumulation of impairments in maternal behavior following postnatal social stress.
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产后社会压力后，孕产妇行为中损害的代际积累。
DOI：
10.1016/j.psyneuen.2017.05.011
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发表时间：
2017-08
影响因子：
3.7
通讯作者：
Murgatroyd C
中科院分区：
文献类型：
--
作者：
Nephew BC;Carini LM;Sallah S;Cotino C;Alyamani RAS;Pittet F;Bradburn S;Murgatroyd C
早期的逆境，如抑郁的母亲护理，可以对后代和后代产生长期的生理和行为影响。暴露于慢性社会压力（CSS），产后抑郁症和焦虑的行为学模型，在哺乳期损害产妇护理，并施加类似的影响，对F1代母鼠后代的强调F0代母鼠。这些变化与皮质酮增加和神经内分泌改变有关。CSS F2后代进一步显示出青少年和成年人的社会行为减少，皮质酮的基础水平降低。本研究探讨了F2 CSS母鼠母性行为改变的代际遗传以及神经内分泌和免疫标记，以探讨母性行为的各个方面是否通过免疫和神经内分泌机制代际遗传。我们发现，母亲照顾行为的缺陷持续到F2代与F2代母鼠表现出普遍抑郁的母亲照顾和增加不安整个哺乳期。这与基础皮质醇减少（与F1母鼠增加相反）、神经内分泌基因表达缺乏变化以及血清ICAM-1（细胞间粘附分子-1）水平降低（炎症和血脑屏障完整性的标志物）一起发生。这些数据支持这样一种假设，即慢性社会压力的影响可以在多代人中积累，从而抑制产妇护理，增加不安情绪，改变免疫系统和下丘脑垂体肾上腺轴的基本功能。
Early adversity such as depressed maternal care can have long-term physiological and behavioral effects on offspring and future generations. Exposure to chronic social stress (CSS), an ethologically model of postpartum depression and anxiety, during lactation impairs maternal care and exerts similar effects on the F1 dam offspring of the stressed F0 dams. These changes associate with increased corticosterone and neuroendocrine alterations. CSS F2 offspring further display decreased social behavior as juveniles and adults and decreased basal levels of corticosterone. This current study investigates the intergenerational inheritance of alterations in maternal behavior in F2 CSS dams together with neuroendocrine and immune markers to explore whether aspects of maternal behavior are intergenerationally inherited through immune and neuroendocrine mechanisms. We find that defects in maternal care behavior persist into the F2 generation with F2 dams exhibiting a pervasively depressed maternal care and increased restlessness throughout lactation. This occurs together with reduced basal cortisol (in contrast to an increase in F1 dams), a lack of changes in neuroendocrine gene expression, and reduced serum ICAM-1 (intercellular adhesion molecule-1) levels - a marker for inflammation and blood–brain barrier integrity. The data support the hypothesis that the effects of chronic social stress can accumulate across multiple generations to depress maternal care, increase restlessness and alter basal functioning of the immune system and hypothalamic pituitary adrenal axis.
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影响因子：
3.6
作者：
Faure, Jacqueline;Uys, Joachim D. K.;Daniels, Willie M. U.
通讯作者：
Daniels, Willie M. U.
DOI：
10.1038/npp.2010.159
发表时间：
2010-12
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1073/pnas.1218253109
发表时间：
2012-12-11
影响因子：
11.1
作者：
Cole, Steven W.;Conti, Gabriella;Suomi, Stephen J.
通讯作者：
Suomi, Stephen J.
影响因子：
3.8
作者：
Gomez-Gonzalez, B.;Escobara, A.
通讯作者：
Escobara, A.
影响因子：
3.3
作者：
Bales, K. L.;Plotsky, P. M.;Carter, C. S.
通讯作者：
Carter, C. S.