Extracellular vesicles-associated tRNA-derived fragments (tRFs): biogenesis, biological functions, and their role as potential biomarkers in human diseases.
Extracellular vesicles-associated tRNA-derived fragments (tRFs): biogenesis, biological functions, and their role as potential biomarkers in human diseases.
复制标题
DOI：
10.1007/s00109-022-02189-0
复制
发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
传统上，转运RNA（transfer RNA，tRNA）特异性地解码信使RNA（messenger RNA，mRNA）并参与蛋白质翻译。tRNA衍生片段（tRFs），也称为tRNA衍生小RNA（tsRNA），是由前和成熟tRNA的特异性切割产生的，并且是一类新定义的功能性小非编码RNA（sncRNA）。根据前体或成熟tRNA的切割位置不同，tRF可分为7种类型：5′-tRNAhalf、3′-tRNAhalf、tRF-1、5′U-tRF、3′-tRF、5′-tRF和i-tRF。研究表明，tRFs在细胞过程中具有多种生物学功能，包括抑制蛋白质翻译、调节应激反应、调节基因表达、参与细胞周期和表观遗传等。越来越多的证据表明，细胞外囊泡（EVs）中的tRFs似乎是各种细胞过程中的调节分子，并在细胞间通讯中发挥重要作用。此外，EV相关tRF的失调与多种癌症的发生和进展相关，它们可以作为癌症诊断的新的潜在生物标志物。本文综述了tRFs的生物学起源和分类，并对EV相关tRFs的生物学功能及其在人类疾病中作为潜在生物标志物的作用进行了讨论。在线版本包含补充材料，可通过10.1007/s 00109 -022-02189-0获得。
Traditionally, transfer RNAs (tRNAs) specifically decoded messenger RNA (mRNA) and participated in protein translation. tRNA-derived fragments (tRFs), also known as tRNA-derived small RNAs (tsRNAs), are generated by the specific cleavage of pre- and mature tRNAs and are a class of newly defined functional small non-coding RNAs (sncRNAs). Following the different cleavage positions of precursor or mature tRNA, tRFs are classified into seven types, 5′-tRNA half, 3′-tRNA half, tRF-1, 5′U-tRF, 3′-tRF, 5′-tRF, and i-tRF. It has been demonstrated that tRFs have a diverse range of biological functions in cellular processes, which include inhibiting protein translation, modulating stress response, regulating gene expression, and involvement in cell cycles and epigenetic inheritance. Emerging evidences have indicated that tRFs in extracellular vesicles (EVs) seem to act as regulatory molecules in various cellular processes and play essential roles in cell-to-cell communication. Furthermore, the dysregulation of EV-associated tRFs has been associated with the occurrence and progression of a variety of cancers and they can serve as novel potential biomarkers for cancer diagnosis. In this review, the biogenesis and classification of tRFs are summarized, and the biological functions of EV-associated tRFs and their roles as potential biomarkers in human diseases are discussed. The online version contains supplementary material available at 10.1007/s00109-022-02189-0.
登录
查看更多内容
DOI：
10.4137/bic.s20764
发表时间：
2014
期刊：
Biomarkers in cancer
影响因子：
--
作者：
Dhahbi JM;Spindler SR;Atamna H;Boffelli D;Martin DI
通讯作者：
Martin DI
影响因子：
16
作者：
Crescitelli R;Lässer C;Szabó TG;Kittel A;Eldh M;Dianzani I;Buzás EI;Lötvall J
通讯作者：
Lötvall J
影响因子：
64.5
作者：
Goodarzi H;Liu X;Nguyen HC;Zhang S;Fish L;Tavazoie SF
通讯作者：
Tavazoie SF
影响因子：
1.5
作者：
Fernandez-Calero, Tamara;Garcia-Silva, Rosa;Cayota, Alfonso
通讯作者：
Cayota, Alfonso
影响因子：
8.8
作者：
Chiou, Ni-Ting;Kageyama, Robin;Ansel, K. Mark
通讯作者：
Ansel, K. Mark