Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene.
Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene.
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DOI：
10.1016/j.canlet.2009.04.033
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发表时间：
2009-11-28
期刊：
影响因子：
9.7
通讯作者：
Saleem, Mohammad
中科院分区：
文献类型：
--
作者：
Saleem, Mohammad
在西方世界，人类每天平均消耗250毫克的三萜类化合物(植物甾醇家族的成员)，主要来自植物油、谷物、水果和蔬菜。在过去的十年中，由于三萜类化合物具有降低胆固醇的特性，人们对它们的兴趣空前高涨，这一现象的证据包括至少25项临床研究、20项专利和目前在世界各地销售的至少10种主要的商业三萜类产品。羽扇豆醇是一种在白菜、青椒、草莓、橄榄、芒果和葡萄中发现的三萜化合物，据报道，它对一系列疾病具有治疗和预防作用。在过去的15年里，世界各地的研究人员做出了巨大的努力，开发出这种奇妙的分子，用于临床治疗各种疾病。这些研究还揭示了羽扇豆醇的作用机制，并提示它是一种具有巨大抗炎潜力的多靶点药物，其靶向的关键分子通路涉及核因子-kappaB(NF-κB)、c-flip、Fas、kras、磷脂酰肌醇-3-激酶(PI3K)/Akt和Wnt/β-catenin。值得注意的是，在有效的治疗剂量下，羽扇豆醇对正常细胞和组织没有毒性。这篇简短的综述详细介绍了为确定羽扇豆醇作为治疗和化学预防药物治疗炎症和癌症的效用而进行的临床前研究。
In the Western world, an average of 250 mg per day of triterpenes (member of phytosterol family), largely derived from vegetable oils, cereals, fruits and vegetables is consumed by humans. During the last decade, there has been an unprecedented escalation of interest in triterpenes due to their cholesterol-lowering properties and evidence of this phenomenon include at least 25 clinical studies, 20 patents and at least 10 major commercially triterpene-based products currently being sold all around the world. Lupeol a triterpene [also known as Fagarsterol] found in white cabbage, green pepper, strawberry, olive, mangoes and grapes was reported to possess beneficial effects as a therapeutic and preventive agent for a range of disorders. Last 15 years have seen tremendous efforts by researchers worldwide to develop this wonderful molecule for its clinical use for the treatment of variety of disorders. These studies also provide insight into the mechanism of action of Lupeol and suggest that it is a multi-target agent with immense anti-inflammatory potential targeting key molecular pathways which involve nuclear factor kappa B (NFκB), cFLIP, Fas, Kras, phosphatidylinositol-3-kinase (PI3K)/Akt and Wnt/β-catenin in a variety of cells. It is noteworthy that Lupeol at its effective therapeutic doses exhibit no toxicity to normal cells and tissues. This mini review provides detailed account of preclinical studies conducted to determine the utility of Lupeol as a therapeutic and chemopreventive agent for the treatment of inflammation and cancer.
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影响因子：
7.2
作者：
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