Influence of frailty on patient global assessment in rheumatoid arthritis
Influence of frailty on patient global assessment in rheumatoid arthritis
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虚弱对类风湿关节炎患者整体评估的影响
DOI：
10.1111/ggi.14375
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发表时间：
2022
影响因子：
3.3
通讯作者：
Kojima T
中科院分区：
文献类型：
--
作者：
Suzuki M;Asai S;Sobue Y;Ohashi Y;Koshima H;Okui N;Ishikawa H;Takahashi N;Terabe K;Kishimoto K;Hattori K;Imagama S;Kojima T
AimPatient Global Assessment（PtGA;范围0-10 cm）是类风湿关节炎（RA）患者自我评估中临床结局（包括身体功能）的重要指标。脆弱是一个概念，不仅包括身体上的脆弱性，也包括精神、心理和社会上的脆弱性。本研究旨在调查RA患者的虚弱对PtGA的影响。方法在2020年6月至8月期间完成虚弱问卷调查的581例RA患者中，包括559名完成Kihon检查表（KCL; 25项问卷，包括7个领域）的患者。比较了虚弱（KCL评分≥8）、虚弱前期（KCL评分4-7）和强健（KCL评分0-3）组之间PtGA ≤1的患者比例。结果在559例患者中，221例（39.5%）有虚弱症状。PtGA ≤1的患者比例在虚弱组（33.9%）显著低于强健组（65.4%，P < 0.001）和虚弱前组（55.7%，P < 0.001）。多变量分析显示，虚弱（vsrobust，OR 0.37，95% CI 0.22-0.69）以及疾病持续时间和压痛关节计数是与PtGA ≤1独立相关的因素。在KCL的各个领域中，日常生活活动能力、体力、孤独和抑郁情绪是PtGA ≤ 1的相关因素。由于脆弱性影响PtGA的身体、精神和社会脆弱性方面，需要多方面的方法，包括炎症抑制，来改善RA患者的PtGA。Geriatr Gerontol Int 2022; 22：399-404。
AimPatient Global Assessment (PtGA; range 0–10 cm) is an important indicator of clinical outcomes, including physical function, in self‐assessment of patients with rheumatoid arthritis (RA). Frailty is a concept that encompasses not only physical, but also mental, psychological and social vulnerability. This study aimed to investigate the influence of frailty on PtGA in patients with RA.MethodsAmong 581 patients with RA who completed a questionnaire survey on frailty between June and August 2020, 559 who completed the Kihon Checklist (KCL; a 25‐item questionnaire with seven domains) were included. The proportion of patients with PtGA ≤1 was compared between the frailty (KCL score ≥8), pre‐frailty (KCL score 4–7) and robust (KCL score 0–3) groups. Factors associated with PtGA ≤1 were examined using multivariate logistic regression models.ResultsOf the 559 patients, 221 (39.5%) had frailty. The proportion of patients with PtGA ≤1 was significantly lower in the frailty group (33.9%) than in the robust (65.4%,P< 0.001) and pre‐frailty (55.7%,P< 0.001) groups. Multivariate analysis revealed that frailty (vsrobust, OR 0.37, 95% CI 0.22–0.69), as well as disease duration and tender joint count, were factors independently associated with PtGA ≤1. When each domain of the KCL was examined, activities of daily living, physical strength, isolation and depressive mood were factors associated with PtGA ≤1.ConclusionFrailty affects PtGA in patients with RA. As frailty impacts the physical, mental and social vulnerability aspects of PtGA, a multifaceted approach, including inflammation suppression, is required to improve PtGA in patients with RA.Geriatr Gerontol Int 2022; 22: 399–404.
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DOI：
--
发表时间：
2010
期刊：
--
影响因子：
--
作者：
D. Aletaha;T. Neogi;A. Silman;Julia Funovits;D. Felson;C. Bingham;N. Birnbaum;G. Burmester;V. Byker
通讯作者：
D. Aletaha;T. Neogi;A. Silman;Julia Funovits;D. Felson;C. Bingham;N. Birnbaum;G. Burmester;V. Byker
影响因子：
7.3
作者：
Motta F;Sica A;Selmi C
通讯作者：
Selmi C
影响因子：
2.5
作者：
Nakajima, Ayako;Sakai, Ryoko;Harigai, Masayoshi
通讯作者：
Harigai, Masayoshi
日本类风湿性关节炎患者虚弱的相关因素：风湿病研究所类风湿性关节炎队列研究的结果
影响因子：
3.4
作者：
T. Furuya;K. Oh;K. Ikari;E. Inoue;E. Tanaka;H. Yamanaka;M. Harigai
通讯作者：
M. Harigai
影响因子：
27.4
作者：
Khan NA;Spencer HJ;Abda EA;Alten R;Pohl C;Ancuta C;Cazzato M;Géher P;Gossec L;Henrohn D;Hetland ML;Inanc N;Jacobs JW;Kerzberg E;Majdan M;Oyoo O;Peredo-Wende RA;Selim ZI;Skopouli FN;Sulli A;Hørslev-Petersen K;Taylor PC;Sokka T;QUEST-RA group
通讯作者：
QUEST-RA group