Correlates and Consequences of High Serum Irisin Concentration in Patients on Hemodialysis: A Longitudinal Analysis.
Correlates and Consequences of High Serum Irisin Concentration in Patients on Hemodialysis: A Longitudinal Analysis.
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DOI：
10.1053/j.jrn.2020.05.005
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Johansen KL
中科院分区：
文献类型：
--
作者：
Chiang JM;Delgado C;Kaysen GA;Segal MR;Chertow GM;Johansen KL
蝴蝶素是肌肉在运动后释放的一种荷尔蒙，作用于白色脂肪细胞，刺激脂肪组织变色。我们的目的是研究虹膜蛋白与血液透析患者虹膜蛋白的相关性及其后果。一项前瞻性队列研究使用了749名接受血液透析的流行患者的数据。用多元线性回归和多变量广义估计方程来确定基线与血清虹膜蛋白浓度变化的相关性。采用比例风险(COX)回归方法评估血清淫羊藿素浓度与死亡时间之间的关系。年龄和BMI与基线和血清虹膜蛋白浓度变化呈负相关。从基线到12个月，较低的肌量与较低的虹膜蛋白浓度相关(−为1.38%/mg/dL(95%可信区间：−2.45，−0.21)，虹膜蛋白浓度下降0.72%(95%可信区间：−：1.48，−0.04)。血清IL-6浓度每升高50%，基线时血清虹膜蛋白浓度升高1.52%(95%CI：0.38，2.66)，1年后虹膜蛋白浓度升高1.04%(95%CI：0.47，1.61)。基线水平的虹膜蛋白浓度与较高的死亡风险相关(HR 1.45，95%CI：1.05 2.00)；超过1年的虹膜蛋白浓度增加与较高的死亡风险相关(HR 1.34，95%CI：1.01，1.79)。在正式的中介分析中，血清IL-6在血清淫羊藿素和死亡率之间的关系中起中介作用。较低的血肌酐(反映较低的肌肉质量)和较高的血清IL-6水平与较高的血清虹膜蛋白浓度相关。更高的血清虹膜蛋白浓度与更高的死亡率相关，这可能是由炎症所介导的。
Irisin is a hormone released by muscle in response to exercise that acts on white adipose cells to stimulate browning of adipose tissue. We aimed to examine irisin correlates and consequences of irisin in patients receiving hemodialysis. A prospective cohort study was conducted using data from 749 prevalent patients receiving hemodialysis. Multivariable linear regression and multivariable generalized estimating equations were used to determine correlates of baseline and change in serum irisin concentration. Proportional hazards (Cox) regression was used to assess the association between serum irisin concentration and time-to-death. Age and BMI were inversely associated with baseline and change in serum irisin concentration. Lower muscle mass as estimated by serum creatinine concentration was associated with lower irisin concentration (−1.38% per mg/dL (95% CI: −2.45, −0.21) and with a 0.72% decrease in irisin concentration (95% CI: −1.48, −0.04) from baseline to 12 months. Each 50% higher serum IL-6 concentration was associated with 1.52% higher serum irisin concentration (95% CI: 0.38, 2.66) at baseline and an increase of 1.04% in irisin concentration over 1 year (95% CI: 0.47, 1.61). Irisin concentration at baseline was associated with higher hazard of death (HR 1.45, 95% CI: 1.05 2.00); an increase in irisin concentration over 1 year was associated with a higher hazard of death (HR 1.34, 95% CI: 1.01, 1.79). In formal mediation analysis, serum IL-6 was a mediator in the association between serum irisin and mortality. Lower serum creatinine (reflecting lower muscle mass) and higher serum IL-6 were associated with higher serum irisin concentrations. Higher serum irisin concentrations were associated with higher mortality, which may be mediated by inflammation.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
血液透析患者血清鸢尾素水平降低与血管钙化增加相关
影响因子：
2.8
作者：
He, Lian;He, Wan-Yu;Zhang, Ai-Hua
通讯作者：
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影响因子：
2.2
作者：
Kraemer, R. R.;Shockett, P.;Castracane, V. D.
通讯作者：
Castracane, V. D.
DOI：
10.1016/0021-9681(78)90058-9
发表时间：
1978-01-01
期刊：
JOURNAL OF CHRONIC DISEASES
影响因子：
--
作者：
TAYLOR, HL;JACOBS, DR;DEBACKER, G
通讯作者：
DEBACKER, G
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影响因子：
4
作者：
Zhao J;Su Z;Qu C;Dong Y
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