Memory CD4 T cells induce selective expression of IL-27 in CD8+ dendritic cells and regulate homeostatic naive T cell proliferation.
Memory CD4 T cells induce selective expression of IL-27 in CD8+ dendritic cells and regulate homeostatic naive T cell proliferation.
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记忆CD4 T细胞在CD8+树突状细胞中诱导IL-27的选择性表达，并调节稳态天真T细胞增殖。
DOI：
10.4049/jimmunol.1101908
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Min B
中科院分区：
文献类型：
--
作者：
Do JS;Visperas A;Oh K;Stohlman SA;Min B
Naïve T cells undergo robust proliferation in lymphopenic conditions, while they remain quiescent in steady-state conditions. However, a mechanism by which naïve T cells are kept from proliferating under steady-state conditions remains unclear. Here we report that memory CD4 T cells are able to limit naïve T cell proliferation within lymphopenic hosts by modulating stimulatory functions of DC. The inhibition was mediated by IL-27, which was primarily expressed in CD8+ DC subsets as the result of memory CD4 T cell-DC interaction. IL-27 appeared to be the major mediator of inhibition as naïve T cells deficient in IL-27R were resistant to memory CD4 T cell mediated inhibition. Finally, IL-27-mediated regulation of T cell proliferation was also observed in steady-state conditions as well as during Ag-mediated immune responses. We propose a new model for maintaining peripheral T cell homeostasis via memory CD4 T cells and CD8+ DC-derived IL-27 in vivo.
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影响因子：
32.4
作者：
Ernst, B;Lee, DS;Surh, CD
通讯作者：
Surh, CD
DOI：
10.1084/jem.20100410
发表时间：
2011-01-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cox JH;Kljavin NM;Ramamoorthi N;Diehl L;Batten M;Ghilardi N
通讯作者：
Ghilardi N
影响因子：
15.3
作者：
Liu, Jianguo;Guan, Xiuqin;Ma, Xiaojing
通讯作者：
Ma, Xiaojing
影响因子：
4.4
作者：
Diveu, Caroline;McGeachy, Mandy J.;Kastelein, Robert A.
通讯作者：
Kastelein, Robert A.
影响因子：
56.9
作者：
Chen, M;Wang, YH;Wang, J
通讯作者：
Wang, J