Statistical estimation of deltoid subcutaneous fat pad thickness: implications for needle length for vaccination.
Statistical estimation of deltoid subcutaneous fat pad thickness: implications for needle length for vaccination.
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DOI：
10.1038/s41598-022-05020-5
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发表时间：
2022-01-20
影响因子：
4.6
通讯作者：
Sebro R
中科院分区：
文献类型：
--
作者：
Sebro R
目前美国疾病控制和预防中心肌内注射针长度指南注射三角肌是基于体重和性别。本研究的目的是（1）评价其他生物特征数据（年龄、性别、身高、体重和体重指数（BMI））是否比体重和性别更能预测三角肌皮下脂肪垫（DSFP）的厚度;（2）评价CDC基于体重的针长指南的性能。这是一项回顾性单中心队列研究，纳入了在2020年1月1日至2021年1月4日期间接受监测PET/CT的386例患者。对患者的年龄、性别、身高、体重、BMI和DSFP的CT测量值进行了评价。男性DSFP与体重、BMI呈正相关（r = 0.67，P < 0.001; r = 0.74，P < 0.001），女性DSFP与体重、BMI呈正相关（r = 0.69，P < 0.001; r = 0.75，P < 0.001）。女性DSFP与年龄呈负相关（r =-0.19，P = 0.013）。年龄和BMI比体重更能预测DSFP。预测DSFP的最佳模型是：1英寸的针头预计将达到85.3%的女性小于200磅的三角肌，98.6%的男性小于260磅。该比率在性别之间存在差异（P < 0.001，比值比（OR）0.08，95%CI（0.02，0.29））。一个1.5英寸的针头预计将达到76.7%的女性大于200磅，75.0%的男性大于260磅的三角肌。目前CDC三角肌肌肉注射针长度指南导致女性和肥胖个体更有可能接受皮下注射。基于年龄和BMI的针长度选择指南更准确。
Current US Centers for Disease Control and Prevention intramuscular injection needle length guidelines for injection fo the deltoid muscle are based on weight and gender. The aims of this study are (1) to evaluate whether other biometric data (age, gender, height, weight and body mass index (BMI)) are better predictors of the thickness of the deltoid subcutaneous fat pad (DSFP) than weight and gender and (2) to evaluate the performance of the CDC weight-based needle length guidelines. This was a retrospective single center cohort study of 386 patients who underwent surveillance PET/CT between 01/01/2020 and 04/01/2021. Patient age, gender, height, weight, BMI and CT measurements of the DSFP were evaluated. DSFP was positively correlated with weight and BMI in men (r = 0.67, P < 0.001; r = 0.74, P < 0.001) and women (r = 0.69, P < 0.001; r = 0.75, P < 0.001) respectively. DSFP was negatively correlated with age in women (r = − 0.19, P = 0.013). Age and BMI were better predictors of DSFP than weight. The best model to predict the DSFP is: A 1-inch needle is expected to reach the deltoid in 85.3% of women less than 200 pounds, and 98.6% of men less than 260 pounds. This rate differed between genders (P < 0.001, odds ratio (OR) 0.08, 95% CI (0.02, 0.29)). A 1.5-inch needle is expected to reach the deltoid in 76.7% of women greater than 200 pounds, and 75.0% of men greater than 260 pounds. Current CDC deltoid intramuscular injection needle length guidelines result in women and obese individuals being more likely to receive subcutaneous injections. Age and BMI based guidelines for needle length selection are more accurate.
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