Aging and adipose tissue: potential interventions for diabetes and regenerative medicine.
Aging and adipose tissue: potential interventions for diabetes and regenerative medicine.
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DOI：
10.1016/j.exger.2016.02.013
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发表时间：
2016-12-15
影响因子：
3.9
通讯作者：
Kirkland, James L.
中科院分区：
文献类型：
--
作者：
Palmer, Allyson K.;Kirkland, James L.
脂肪组织功能障碍随着年龄的增长而发生，并具有全身效应，包括外周胰岛素抵抗、异位脂质沉积和炎症。随着年龄的增长，脂肪组织中的细胞衰老和祖细胞功能障碍等基本衰老机制可能成为年龄相关疾病的潜在治疗靶点。在这篇综述中，我们研究了脂肪组织在健康个体中的作用，并探讨了衰老如何导致脂肪组织功能障碍、再分布和基因调控的变化。脂肪组织在长寿中起着核心作用，仅限于脂肪组织的干预可能会影响寿命。相反，肥胖可能代表一种加速衰老的状态。我们以II型糖尿病和再生医学为例，讨论了针对脂肪组织中基本衰老机制（包括细胞衰老）的潜在治疗潜力。我们认为，在脂肪干细胞用于再生医学策略的研究中，衰老不应被忽视，因为老年患者占需要这种治疗的个体的很大一部分。
Adipose tissue dysfunction occurs with aging and has systemic effects, including peripheral insulin resistance, ectopic lipid deposition, and inflammation. Fundamental aging mechanisms, including cellular senescence and progenitor cell dysfunction, occur in adipose tissue with aging and may serve as potential therapeutic targets in age-related disease. In this review, we examine the role of adipose tissue in healthy individuals and explore how aging leads to adipose tissue dysfunction, redistribution, and changes in gene regulation. Adipose tissue plays a central role in longevity, and interventions restricted to adipose tissue may impact lifespan. Conversely, obesity may represent a state of accelerated aging. We discuss the potential therapeutic potential of targeting basic aging mechanisms, including cellular senescence, in adipose tissue, using type II diabetes and regenerative medicine as examples. We make the case that aging should not be neglected in the study of adipose-derived stem cells for regenerative medicine strategies, as elderly patients make up a large portion of individuals in need of such therapies.
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