Skin barrier damaging and repairing process: A new application field of dermoscopy
Skin barrier damaging and repairing process: A new application field of dermoscopy
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皮肤屏障损伤与修复过程：皮肤镜的新应用领域
DOI：
10.1111/jocd.13643
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
郑跃
中科院分区：
文献类型：
--
作者：
叶聪秀;易金玲;赖维;郑跃
背景资料：虽然越来越多的无创检测技术被用于皮肤屏障完整性和功能的评估，但更准确、直观、方便的检测方法仍有待探索和发展。目的：探讨皮肤屏障损伤和修复过程中皮肤镜下特征性图像变化及其与皮肤生理指标的关系。选择25例前臂正常皮肤的健康受试者，按手术次数（30、35、40次）分为3组。结果：不同时间胶带剥离后即刻，表皮细胞残留量及微血管图像均不同，在同一部位同时进行皮肤镜检查及经皮水分丢失（TEWL）、表面水合作用及L*a*B* 值测定。在皮肤屏障修复过程中，30次、35次和40次剥脱皮肤在皮肤镜下观察结痂时间分别为14、7和3天。结论：在皮肤屏障不同损伤程度的不同时间点及修复过程中，皮肤镜下可观察到不同程度的皮肤屏障损伤的独特表现。将皮肤镜技术与皮肤指标评价技术相结合，可以更准确、更准确地观察和评价皮肤屏障的完整性和功能。
Background: Although more and more noninvasive detection technologies have been used in assessing skin barrier integrity and functions, more accurate, intuitive, and convenient detective methods still needed to be explored and developed.Aims: To investigate the characteristic image changes under the ermoscopy and to explore the relationship with skin physiological indexes in skin barrier damaging and repairing process.Patients/Methods: 25 healthy subjects with normal skin in forearm were included and divided into different groups according to the operated strips numbers (30, 35, and 40 times). Before tape stripping, and immediately, 3, 7, 14, and 21 days after tape stripping, dermoscopic examination and skin transepidermal water loss (TEWL), surface hydration, and L*a*b* value were simultaneously tested in the same region.Results: Immediately after different times tape stripping, the amount of cuticle cells residues and the microvascular images were different. In skin barrier repairing process, the scab forming time observed under dermoscopy was day 14, day 7, and day 3 on 30 times, 35 times, and 40 times stripped skin, respectively. A small amount of cuticle cells and blurry vessels could be identified in hydration value 40 group.Conclusions: Unique manifestations could be observed under dermoscopy in different time points of skin barrier with various degree of injury and in skin barrier repairing process. By combining dermoscopy and skin indexes assessing technologies, the skin barrier integrity and function could be observed and evaluated more accurately and precisely.
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DOI：
10.1111/j.1467-2494.1991.tb00561.x
发表时间：
1991-08-01
影响因子：
2.3
作者：
CHARDON, A;CRETOIS, I;HOURSEAU, C
通讯作者：
HOURSEAU, C
影响因子：
3
作者：
A. Weerheim;M. Ponec
通讯作者：
A. Weerheim;M. Ponec
影响因子：
1.4
作者：
A. Lake;B. Jones
通讯作者：
A. Lake;B. Jones
影响因子：
2.2
作者：
Bashir, SJ;Chew, AL;Maibach, HI
通讯作者：
Maibach, HI
影响因子：
10.3
作者：
Benfeldt;Serup;Menné
通讯作者：
Benfeldt;Serup;Menné