Shear Stress Enhances Chemokine Secretion from Chlamydia pneumoniae-infected Monocytes.
Shear Stress Enhances Chemokine Secretion from Chlamydia pneumoniae-infected Monocytes.
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DOI：
10.1007/s12195-013-0291-x
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发表时间：
2013-09-01
影响因子：
2.8
通讯作者：
Ramasubramanian, Anand K.
中科院分区：
文献类型：
--
作者：
Evani, Shankar J.;Dallo, Shatha F.;Murthy, Ashlesh K.;Ramasubramanian, Anand K.
肺炎衣原体是一种常见的呼吸道病原体，被认为是动脉粥样硬化的高度危险因素。C.肺炎链球菌通过感染的单核细胞从肺播散到体循环中，并停留在动脉粥样硬化部位。在运输过程中，C.循环中的肺炎感染的单核细胞由于血流而受到剪切应力。机械刺激对受感染单核细胞的影响在C.肺炎感染和炎症。我们假设流体切应力改变了C.肺炎感染的单核细胞，并有助于免疫细胞募集到组织损伤部位。使用体外血流模型，我们测定了7.5dyn/cm ~ 2的生理剪切应力对C.肺炎感染的单核细胞增强了几种趋化因子的产生，这又与显著大量单核细胞的募集相关。综上所述，这些结果表明，协同作用之间的机械和化学因素在C。肺炎感染和相关炎症。
Chlamydia pneumoniae is a common respiratory pathogen that is considered a highly likely risk factor for atherosclerosis. C. pneumoniae is disseminated from the lung into systemic circulation via infected monocytes and lodges at the atherosclerotic sites. During transit, C. pneumoniae-infected monocytes in circulation are subjected to shear stress due to blood flow. The effect of mechanical stimuli on infected monocytes is largely understudied in the context of C. pneumoniae infection and inflammation. We hypothesized that fluid shear stress alters the inflammatory response of C. pneumoniae-infected monocytes and contributes to immune cell recruitment to the site of tissue damage. Using an in vitro model of blood flow, we determined that a physiological shear stress of 7.5 dyn/cm2 for 1 h on C. pneumoniae-infected monocytes enhances the production of several chemokines, which in turn is correlated with the recruitment of significantly large number of monocytes. Taken together, these results suggest synergistic interaction between mechanical and chemical factors in C. pneumoniae infection and associated inflammation.
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