Interleukin-6, MCP-1, IP-10, and MIG are sequentially expressed in cerebrospinal fluid after subarachnoid hemorrhage.
Interleukin-6, MCP-1, IP-10, and MIG are sequentially expressed in cerebrospinal fluid after subarachnoid hemorrhage.
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蛛网膜下腔出血后脑脊液中白细胞介素6、MCP-1、IP-10和MIG依次表达。
DOI：
10.1186/s12974-016-0675-7
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发表时间：
2016-08-30
影响因子：
9.3
通讯作者：
Takayasu M
中科院分区：
文献类型：
--
作者：
Niwa A;Osuka K;Nakura T;Matsuo N;Watabe T;Takayasu M
白细胞介素-6 （IL-6）是一种炎症细胞因子，在蛛网膜下腔出血（SAH）后脑脊液（CSF）中起重要作用。趋化因子是调节单核/巨噬细胞和淋巴细胞向炎症部位运输的趋化因子。然而，关于SAH后脑脊液中这些细胞因子的时间表达的研究尚未报道。采用ELISA试剂盒检测10例SAH患者脑脊液中IL-6、单核细胞趋化蛋白-1 （MCP-1）、干扰素γ诱导蛋白-10 （IP-10）和干扰素γ诱导的单因子的浓度，为期14天。所有动脉瘤均位于前循环。未破裂动脉瘤患者的脑脊液样本作为对照。IL-6浓度在疾病急性期显著升高。MCP-1浓度在第1 ~ 5天呈上升趋势，在第3天达到峰值，随后呈下降趋势。IP-10和MIG浓度逐渐升高，在第5天达到峰值，然后逐渐降低。IL-6与MCP-1、IP-10与MIG在第5天的最高水平有较强的相关性。预后差的患者IL-6的最高水平远高于预后好的患者。本研究表明，SAH后IL-6水平的升高可诱导CSF中MCP-1的表达，随后是IP-10和MIG的表达升高。这些细胞因子水平的动态变化可能诱发炎症，并可能与SAH后迟发性缺血性神经功能缺损的发展密切相关。本文的在线版本（doi:10.1186/s12974-016-0675-7）包含补充材料，可供授权用户使用。
Interleukin-6 (IL-6), an inflammatory cytokine, plays important roles in cerebrospinal fluid (CSF) after subarachnoid hemorrhage (SAH). Chemokines are chemoattractant cytokines that regulate trafficking of monocytes/macrophages and lymphocytes to sites of inflammation. However, no studies have been reported regarding the temporal expression of these cytokines in CSF after SAH. The concentrations of IL-6, monocyte chemoattractant protein-1 (MCP-1), interferon-γ-inducible protein-10 (IP-10), and monokine induced by interferon-γ (MIG) in the CSF of ten patients with SAH were measured using ELISA kits over a period of 14 days. All aneurysms were located in the anterior circulation. CSF samples from patients with unruptured aneurysms were used as controls. The concentration of IL-6 significantly increased during the acute stage of the disease. The concentration of MCP-1 increased from days 1 to 5, peaking on day 3, and decreased thereafter. The concentrations of IP-10 and MIG progressively increased, peaked on day 5, and then gradually decreased. There were strong correlations between the maximum levels of IL-6 and MCP-1 and IP-10 and MIG on day 5. The maximum level of IL-6 was much higher in poor outcome patients than in good outcome patients. The present investigation demonstrated that increases in IL-6 levels may induce the expression of MCP-1 in CSF after SAH, followed by increases in the expression of IP-10 and MIG. Dynamic changes in the levels of these cytokines may induce inflammation and may be closely associated with the development of delayed ischemic neurological deficits after SAH. The online version of this article (doi:10.1186/s12974-016-0675-7) contains supplementary material, which is available to authorized users.
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影响因子：
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通讯作者：
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