SOCS Proteins as Regulators of Inflammatory Responses Induced by Bacterial Infections: A Review.
SOCS Proteins as Regulators of Inflammatory Responses Induced by Bacterial Infections: A Review.
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DOI：
10.3389/fmicb.2017.02431
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发表时间：
2017
影响因子：
5.2
通讯作者：
Dennis VA
中科院分区：
文献类型：
--
作者：
Duncan SA;Baganizi DR;Sahu R;Singh SR;Dennis VA
严重的细菌感染可导致急性和慢性炎症。先天免疫是通过模式识别受体 (PRR)，尤其是 Toll 样受体 (TLR) 识别细菌上保守的分子模式来对抗入侵细菌病原体的第一种防御机制。 TLR 可识别不同的病原体相关分子模式 (PAMP)，这些模式通过诱导多种炎症基因的表达，在先天免疫反应中发挥关键作用。因此，免疫细胞的激活受到使用 Janus 激酶/信号转导器和转录激活剂 (JAK/STAT) 信号通路的细胞因子以及 TLR 的微生物识别的调节。该系统受到各种内源性分子的严格控制，以允许对感染进行适当调节和安全的宿主免疫反应。细胞因子信号传导抑制蛋白 (SOCS) 家族蛋白是微生物病原体诱导的细胞因子信号传导的核心调节因子之一，主要通过抑制 JAK/STAT 信号级联的激活。这篇综述提供了有关 SOCS 蛋白在细菌感染过程中作用的最新知识，重点是它们诱导和调节抗菌免疫反应的机制。此外，还讨论了 SOCS 蛋白在细菌逃避宿主防御的多种过程和细菌感染结果中的含义，以及这些蛋白为未来靶向抗菌治疗提供的可能性。
Severe bacterial infections can lead to both acute and chronic inflammatory conditions. Innate immunity is the first defense mechanism employed against invading bacterial pathogens through the recognition of conserved molecular patterns on bacteria by pattern recognition receptors (PRRs), especially the toll-like receptors (TLRs). TLRs recognize distinct pathogen-associated molecular patterns (PAMPs) that play a critical role in innate immune responses by inducing the expression of several inflammatory genes. Thus, activation of immune cells is regulated by cytokines that use the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway and microbial recognition by TLRs. This system is tightly controlled by various endogenous molecules to allow for an appropriately regulated and safe host immune response to infections. Suppressor of cytokine signaling (SOCS) family of proteins is one of the central regulators of microbial pathogen-induced signaling of cytokines, principally through the inhibition of the activation of JAK/STAT signaling cascades. This review provides recent knowledge regarding the role of SOCS proteins during bacterial infections, with an emphasis on the mechanisms involved in their induction and regulation of antibacterial immune responses. Furthermore, the implication of SOCS proteins in diverse processes of bacteria to escape host defenses and in the outcome of bacterial infections are discussed, as well as the possibilities offered by these proteins for future targeted antimicrobial therapies.
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DOI：
10.1038/nrmicro3480
发表时间：
2015-10
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Brown L;Wolf JM;Prados-Rosales R;Casadevall A
通讯作者：
Casadevall A
影响因子：
6.7
作者：
Carow B;Reuschl AK;Gavier-Widén D;Jenkins BJ;Ernst M;Yoshimura A;Chambers BJ;Rottenberg ME
通讯作者：
Rottenberg ME
影响因子：
4.4
作者：
Dalpke, AH;Opper, S;Heeg, K
通讯作者：
Heeg, K
影响因子：
3.4
作者：
Brannon MK;Davis JM;Mathias JR;Hall CJ;Emerson JC;Crosier PS;Huttenlocher A;Ramakrishnan L;Moskowitz SM
通讯作者：
Moskowitz SM
影响因子：
5.2
作者：
Betts-Hampikian HJ;Fields KA
通讯作者：
Fields KA