The Chlamydial Type III Secretion Mechanism: Revealing Cracks in a Tough Nut.
The Chlamydial Type III Secretion Mechanism: Revealing Cracks in a Tough Nut.
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DOI：
10.3389/fmicb.2010.00114
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发表时间：
2010
影响因子：
5.2
通讯作者：
Fields KA
中科院分区：
文献类型：
--
作者：
Betts-Hampikian HJ;Fields KA
今天的衣原体科成员含有寄生细菌，这些寄生细菌已经与它们的真核宿主共同进化了数亿年。同样，所有基因组中编码的III型分泌系统已被完善，以补充衣原体如此成功地定殖的独特专性细胞内小生境。所有这些适应都是在明显缺乏水平基因转移的情况下发生的，而水平基因转移是在其他革兰氏阴性、表达III型的细菌中创造广泛多样性的原因。其结果是一个系统，在许多方面，独特的衣原体。大量的信息已经积累，揭示了衣原体分泌系统如何发挥作用，并有助于一个专性细胞内的生活方式显着光。虽然整体机制肯定与同源系统相似，但已经出现了衣原体分泌系统对生存和毒力都至关重要的图像。许多明显的差异，一些微妙的和一些深刻的，区分衣原体III型分泌物从其他人。在此，我们提供了一个全面的审查，目前的知识状态有关的衣原体III型分泌机制。我们专注于方面，明显衣原体和评论如何影响这个重要的系统衣原体发病机制。在缺乏易驾驭的遗传系统的情况下，掌握这个迷人的系统一直是一个挑战。然而，这个坚韧问题的表面已经得到了解决，未来的前景将是富有成效的。
Present-day members of the Chlamydiaceae contain parasitic bacteria that have been co-evolving with their eukaryotic hosts over hundreds of millions of years. Likewise, a type III secretion system encoded within all genomes has been refined to complement the unique obligate intracellular niche colonized so successfully by Chlamydia spp. All this adaptation has occurred in the apparent absence of the horizontal gene transfer responsible for creating the wide range of diversity in other Gram-negative, type III-expressing bacteria. The result is a system that is, in many ways, uniquely chlamydial. A critical mass of information has been amassed that sheds significant light on how the chlamydial secretion system functions and contributes to an obligate intracellular lifestyle. Although the overall mechanism is certainly similar to homologous systems, an image has emerged where the chlamydial secretion system is essential for both survival and virulence. Numerous apparent differences, some subtle and some profound, differentiate chlamydial type III secretion from others. Herein, we provide a comprehensive review of the current state of knowledge regarding the Chlamydia type III secretion mechanism. We focus on the aspects that are distinctly chlamydial and comment on how this important system influences chlamydial pathogenesis. Gaining a grasp on this fascinating system has been challenging in the absence of a tractable genetic system. However, the surface of this tough nut has been scored and the future promises to be fruitful and revealing.
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影响因子：
3.6
作者：
Blaylock B;Berube BJ;Schneewind O
通讯作者：
Schneewind O
影响因子：
3.5
作者：
Bailey, Leslie;Gylfe, Asa;Bergstrom, Sven
通讯作者：
Bergstrom, Sven
DOI：
10.1073/pnas.0304579101
发表时间：
2004-01-06
影响因子：
11.1
作者：
Fadouloglou, VE;Tampakaki, AP;Kokkinidis, M
通讯作者：
Kokkinidis, M
影响因子：
3.2
作者：
Case, Elizabeth Di Russo;Peterson, Ellena M.;Tan, Ming
通讯作者：
Tan, Ming
影响因子：
3.2
作者：
Akeda, Y;Galán, JE
通讯作者：
Galán, JE