Gray matter structures associated with neuroticism: A meta-analysis of whole-brain voxel-based morphometry studies.
Gray matter structures associated with neuroticism: A meta-analysis of whole-brain voxel-based morphometry studies.
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与神经质相关的灰质结构：基于全脑体素的形态测量研究的荟萃分析
DOI：
10.1002/hbm.25395
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发表时间：
2021-06-15
影响因子：
4.8
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Liu X;Lai H;Li J;Becker B;Zhao Y;Cheng B;Wang S
神经质是一种主要的高阶人格特质，并且与心理和生理健康结果密切相关。尽管越来越多的研究已经确定了神经质的神经结构标记，但结果仍然高度不一致。为了描述神经质与灰质（GM）结构变化之间的稳健关联，本项荟萃分析使用各向异性效应量符号差异映射（AES - SDM）研究了基于体素的形态测量（VBM）研究之间的一致性。共纳入了13项研究，包括2278名健康受试者（1275名女性，年龄29.20 ± 14.17岁）。我们的分析显示，神经质始终与一个横跨双侧背侧前扣带回皮质并延伸至相邻内侧前额叶皮质（dACC/mPFC）的集群的灰质结构相关。荟萃回归分析表明，神经质 - 灰质关联不受年龄和性别影响。总体而言，我们的研究是首个探索神经质大脑结构相关性的全脑荟萃分析，这些发现可能对针对有精神障碍风险的高神经质个体进行干预有启示意义，干预可针对dACC/mPFC。
在这项荟萃分析中，我们基于先前的全脑基于体素的形态测量（VBM）研究，使用各向异性效应量符号差异映射（AES - SDM）来研究神经质与灰质（GM）结构之间的关联。我们的分析显示，神经质始终与一个横跨双侧背侧前扣带回皮质并延伸至相邻内侧前额叶皮质（dACC/mPFC）的集群的灰质结构相关。我们的发现可能有助于阐明神经质个体差异的神经机制，并确定有希望的神经质干预目标，这可能会降低焦虑和情绪障碍的风险。
Neuroticism is major higher‐order personality trait and has been robustly associated with mental and physical health outcomes. Although a growing body of studies have identified neurostructural markers of neuroticism, the results remained highly inconsistent. To characterize robust associations between neuroticism and variations in gray matter (GM) structures, the present meta‐analysis investigated the concurrence across voxel‐based morphometry (VBM) studies using the anisotropic effect size signed differential mapping (AES‐SDM). A total of 13 studies comprising 2,278 healthy subjects (1,275 females, 29.20 ± 14.17 years old) were included. Our analysis revealed that neuroticism was consistently associated with the GM structure of a cluster spanning the bilateral dorsal anterior cingulate cortex and extending to the adjacent medial prefrontal cortex (dACC/mPFC). Meta‐regression analyses indicated that the neuroticism‐GM associations were not confounded by age and gender. Overall, our study is the first whole‐brain meta‐analysis exploring the brain structural correlates of neuroticism, and the findings may have implications for the intervention of high‐neuroticism individuals, who are at risk of mental disorders, by targeting the dACC/mPFC. In this meta‐analysis, we used the anisotropic effect size signed differential mapping (AES‐SDM) to investigate the association between neuroticism and gray matter (GM) structures based on previous whole‐brain voxel‐based morphometry (VBM) studies. Our analysis revealed that neuroticism was consistently associated with the GM structure of a cluster spanning the bilateral dorsal anterior cingulate cortex and extending to the adjacent medial prefrontal cortex (dACC/mPFC). Our findings may shed light on the elucidation of the neural mechanisms that underpin individual variations in neuroticism and the determination of promising intervention targets for neuroticism, which may reduce the risk of anxiety and mood disorders.
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影响因子：
1.9
作者：
Canli, T;Zhao, Z;Gabrieli, JDE
通讯作者：
Gabrieli, JDE
影响因子：
2
作者：
Cheng, Dominic T.;Richards, Jennifer;Helmstetter, Fred J.
通讯作者：
Helmstetter, Fred J.
影响因子：
3.3
作者：
Benedict, Ralph H. B.;Schwartz, Carolyn E.;Zivadinov, Robert
通讯作者：
Zivadinov, Robert
影响因子：
7.6
作者：
CHURCH, AT
通讯作者：
CHURCH, AT
影响因子：
56.9
作者：
Canli, T;Sivers, H;Gabrieli, JDE
通讯作者：
Gabrieli, JDE