Threshold thickness of foveal outer nuclear layer associated with outcomes of photodynamic therapy in central serous chorioretinopathy
Threshold thickness of foveal outer nuclear layer associated with outcomes of photodynamic therapy in central serous chorioretinopathy
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中心凹外核层阈值厚度与中心性浆液性脉络膜视网膜病变光动力治疗结果相关
DOI：
10.1038/s41433-021-01762-0
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Xu Gezhi
中科院分区：
文献类型：
--
作者：
Yu Jia;Ye Xiaofeng;Li Lei;Jiang Chunhui;Chang Qing;Xu Gezhi
目的探讨中心性浆液性脉络膜视网膜病变（CSC）患者接受半剂量光动力疗法（PDT）治疗后，中心凹外核层（ONL）的阈值厚度与良好视力结果的相关性。方法将CSC患者根据半剂量PDT治疗后1年的最佳矫正视力（BCVA）是否为20/20或低于20/20分为两组。分别建立3个多变量logistic回归模型，以确定PDT前中心凹ONL厚度、PDT前后中心凹ONL厚度比值（CSC眼与正常对侧眼中心凹ONL厚度比值）对半剂量PDT预后的预测价值。比较两组受试者工作特征曲线（AUC）下的面积，并确定最佳截断值。PDT前中心凹ONL厚度、PDT前和PDT后中心凹ONL厚度比值均为半剂量PDT后疗效的独立预测因素（均P < 0.05）。PDT后中心凹ONL厚度比值的AUC显著高于其他两个参数的AUC（0.940 vs 0.840和0.882，DeLong检验：均P < 0.05），截断值为0.81。中心凹ONL厚度比为0.81或更大的活动CSC眼在半剂量PDT后可能保留20/20的BCVA。他们被认为是合理的，等待视网膜下液体自发消退。
ObjectivesTo investigate the threshold thickness of the foveal outer nuclear layer (ONL) associated with favourable visual outcome after half-dose photodynamic therapy (PDT) in patients with central serous chorioretinopathy (CSC).MethodsThe CSC patients were divided into two groups according to whether their best-corrected visual acuity (BCVA) at 1 year after half-dose PDT was 20/20 or worse than 20/20. Three multivariable logistic regression models were respectively created to determine the prognostic value of the pre-PDT foveal ONL thickness, the pre- and the post-PDT foveal ONL thickness ratio, which was defined as the foveal ONL thickness in the CSC eye to that in the normal contralateral eye, for predicting the outcome of half-dose PDT. The areas under the receiver operating characteristic curves (AUCs) were compared and the best cut-off values were determined, respectively.ResultsTotally, 134 patients were included. The pre-PDT foveal ONL thickness, the pre-PDT and the post-PDT foveal ONL thickness ratios were all independent predictors of the outcome after half-dose PDT in their respective model (allP< 0.05). The AUC of the post-PDT foveal ONL thickness ratio was significantly higher than the AUCs of the other two parameters (0.940 vs 0.840 and 0.882, DeLong test: bothP< 0.05), with the cut-off value of 0.81.ConclusionsThe threshold of the foveal ONL thickness ratio is 0.81. Active CSC eyes with a foveal ONL thickness ratio of 0.81 or more could probably retain BCVA of 20/20 after half-dose PDT. They were considered reasonable to wait for spontaneous resolution of sub-retinal fluid.
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半剂量光动力治疗前感光层变化与中心性浆液性脉络膜视网膜病变的功能和解剖结果之间的关系
DOI：
10.1038/s41433-020-1018-6
发表时间：
2020-06
期刊：
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影响因子：
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DOI：
10.35248/2593-8509.16.1.i101
发表时间：
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